ArticleInternational wound journal2018
Negative pressure wound treatment with computer-controlled irrigation/instillation decreases bacterial load in contaminated wounds and facilitates wound closure.
Article in International wound journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Oncologic feasibility for negative pressure wound therapy application in surgical wounds: A meta-analysis.International wound journal · 2022Pooled it
- Clinical application and efficacy of negative pressure wound therapy with instillation and dwell time (NPWTi-d): A systematic review and meta-analysis.International wound journal · 2020Pooled it
- A randomized controlled trial evaluating effects of prophylactic irrigation-suction near pancreaticojejunostomy on postoperative pancreatic fistula after pancreaticoduodenectomy.Langenbeck's archives of surgery · 2023Trial
- Negative Pressure Wound Therapy Modulates Wound pH and Bacterial Invasion inPlastic and reconstructive surgery. Global open · 2026Article
- Long term experiences with negative pressure wound therapy in combination with polyhexanid solution instillation technique for treatment of posttraumatic infections and osteomyelitis.Langenbeck's archives of surgery · 2026Article
- Investigation of Optimal Parameters Setting for Negative Pressure Wound Therapy With Instillation and Dwell Time for Hard-To-Heal Wounds With Necrotic Tissue.International wound journal · 2025Observational
- [Perioperative management of wounds associated with secondary sternal osteomyelitis and/or mediastinitis after sternotomy and its clinical effects].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2024Observational
- Skin Inflammation with a Focus on Wound Healing.Advances in wound care · 2023Review
- Biofilm and wound healing: from bench to bedside.European journal of medical research · 2023Review
- Negative Pressure Wound Therapy With Instillation and Dwell Time: Mechanisms of Action Literature Review.Eplasty · 2023Review
- Is Instillational Topical Negative Pressure Wound Therapy in Peri-Prosthetic Infections of the Breast Effective? A Pilot Study.Journal of personalized medicine · 2022Article
- [Comparative Analysis of Clinical Efficacy of Negative Pressure Wound Therapy Plus Lavage System in the Treatment of Wagner Grade 3-5 Diabetic Foot Ulcers Combined with Infection].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Article
- The Value of Negative-Pressure Wound Therapy and Flap Surgery in Hidradenitis Suppurativa - A Single Center Analysis of Different Treatment Options.Frontiers in surgery · 2022Article
- Novel imaging methods reveal positive impact of topical negative pressure application on tissue perfusion in an in vivo skin model.International wound journal · 2021Article
- NPWTi allows safe delayed free flap repair of Gustilo IIIb injuries: A prospective case series.Regenerative therapy · 2021Article
- Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications.Seminars in plastic surgery · 2021Review
- Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy DuringAdvances in wound care · 2021Article
- Article
- Negative pressure wound therapy with instillation and dwell time (NPWTi-d) with V. A. C. VeraFlo in traumatic, surgical, and chronic wounds-A helpful tool for decontamination and to prepare successful reconstruction.International wound journal · 2020Article
- Limb salvage procedure in immunocompromised patients with therapy-resistant leg ulcers-The value of ultra-radical debridement and instillation negative-pressure wound therapy.International wound journal · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial wound contamination is known to be a hindrance to wound healing. Negative pressure wound therapy (NPWT) with or without irrigation is known to optimise conditions in problem wounds. The aim of this study was to investigate the influence of computer-controlled wound irrigation with NPWT on the bacterial load in contaminated wounds. A total of 267 patients were treated with NPWT with automated instillation because of problematic wounds using an antiseptic instillation solution. In 111 patients, a minimum of 4 operative procedures were necessary, and swabs were taken at least at the first and at the fourth operation in a standardised procedure. The number of different bacteria and the amount of bacteria were analysed during the course. In a subgroup of 51 patients, swabs were taken at all 4 operative procedures and analysed separately. In an overall analysis, the number of different bacteria and the amount of bacteria significantly decreased independent of wound localisation and diagnosis. NPWT with automated instillation demonstrates a positive influence in the reduction of bacterial load in problem wounds. Thus, it may help to optimise wound conditions before definite wound closure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.