Evidence map›Paper›PMID 29974543›Full record

ArticleJournal of mass spectrometry : JMS2018

Rapid analysis of ricin using hot acid digestion and MALDI-TOF mass spectrometry.

Dapeng Chen, Wayne A Bryden, Catherine Fenselau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of mass spectrometry : JMS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Microwave supported hydrolysis preparesInternational journal of mass spectrometry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dapeng ChenDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0001-8412-581X
Wayne A BrydenZeteo Tech Inc., Sykesville, MD, USA.
Catherine FenselauDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0003-4979-0229

Funding

Orbitrap Fusion Tribrid Mass SpectrometerS10OD019938 · OD · UNIV OF MARYLAND, COLLEGE PARK · PI FENSELAU, CATHERINE C · 2015 to 2015
$600k
NIH HHS S10 OD019938US Army Research Office W911NF-15-C-0243
6 · The paper itself

Abstract

Ricin is a protein toxin of considerable interest in forensics. A novel strategy is reported here for rapid detection of ricin based on microwave-assisted hot acid digestion and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry. Ricin samples are subjected to aspartate-selective hydrolysis, and biomarker peptide products are characterized by mass spectrometry. Spectra are obtained using post source decay and searched against a protein database. Several advantages are offered by chemical hydrolysis, relative to enzymatic hydrolysis, notably speed, robustness, and the production of heavier biomarkers. Agglutinin contamination is reliably recognized, as is the disulfide bond strongly characteristic of ricin.

Indexed as

Acetic AcidBiomarkersHot TemperatureMicrowavesPeptide FragmentsPeptide MappingProteomicsRicinSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAcetic AcidBiomarkersPeptide FragmentsRicinagglutinincurved field reflectronhot acid digestionMALDI-TOFpost source decayprotein toxinsricin

Identifiers

PMID29974543
PMCPMC7278220

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.