ArticleInternational journal of cancer2018
Fountain of youth for squamous cell carcinomas? On the epigenetic age of non-small cell lung cancer and corresponding tumor-free lung tissues.
Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Impact of age, antiretroviral therapy, and cancer on epigenetic aging in people living with HIV.Cancer medicine · 2023Article
- Association of Epigenetic Age Acceleration With Risk Factors, Survival, and Quality of Life in Patients With Head and Neck Cancer.International journal of radiation oncology, biology, physics · 2021Article
- Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk.Clinical epigenetics · 2020Article
- Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors.Journal of the National Cancer Institute · 2019Article
- Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy.Clinical epigenetics · 2019Article
- miR-210-3p regulates the proliferation and apoptosis of non-small cell lung cancer cells by targeting SIN3A.Experimental and therapeutic medicine · 2019Article
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Authors and funding
9 authors.
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Abstract
Aging affects the core processes of almost every organism, and the functional decline at the cellular and tissue levels influences disease development. Recently, it was shown that the methylation of certain CpG dinucleotides correlates with chronological age and that this epigenetic clock can be applied to study aging-related effects. We investigated these molecular age loci in non-small cell lung cancer (NSCLC) tissues from patients with adenocarcinomas (AC) and squamous cell carcinomas (SQC) as well as in matched tumor-free lung tissue. In both NSCLC subtypes, the calculated epigenetic age did not correlate with the chronological age. In particular, SQC exhibited rejuvenation compared to the corresponding normal lung tissue as well as with the chronological age of the donor. Moreover, the younger epigenetic pattern was associated with a trend toward stem cell-like gene expression patterns. These findings show deep phenotypic differences between the tumor entities AC and SQC, which might be useful for novel therapeutic and diagnostic approaches.
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