Evidence map›Paper›PMID 29974392›Full record

ArticlePurinergic signalling2018

Expression of P2X1 receptors in somatostatin-containing cells in mouse gastrointestinal tract and pancreatic islets of both mouse and human.

Ruihua Ji, Jiao Zhu, Dan Wang, Qian-Qian Sui, Gillian E Knight, Geoffrey Burnstock, Hongbin Yuan, Zhenghua Xiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Somatostatin as an Active Substance in the Mammalian Enteric Nervous System.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ruihua JiDepartment of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
Jiao ZhuDepartment of Neurobiology, MOE Key Laboratory of Molecular Neurobiology, Ministry of Education, Neuroscience Research Centre of Changzheng Hospital, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Dan WangDepartment of Neurobiology, MOE Key Laboratory of Molecular Neurobiology, Ministry of Education, Neuroscience Research Centre of Changzheng Hospital, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Qian-Qian SuiDepartment of Neurobiology, MOE Key Laboratory of Molecular Neurobiology, Ministry of Education, Neuroscience Research Centre of Changzheng Hospital, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Gillian E KnightAutonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK.
Geoffrey BurnstockAutonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK.
Hongbin YuanDepartment of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. moc.nuyila@yyzcjfj.com.
Zhenghua XiangDepartment of Neurobiology, MOE Key Laboratory of Molecular Neurobiology, Ministry of Education, Neuroscience Research Centre of Changzheng Hospital, Second Military Medical University, Shanghai, 200433, People's Republic of China. zhxiang@hotmail.com.ORCID http://orcid.org/0000-0001-7891-5305
Second Military Medical University · CNRoland Hill (United Kingdom) · GBThe University of Melbourne · AU

Funding

the National Natural Science Foundation of P. R. China 81471260the Qiannian Science Foundation of Second Military Medical University of P.L.A 2017QN15the Qingnian Science Foundation of Changzheng Hospital, Shanghai, People's Republic of China 2016CZQN05
6 · The paper itself

Abstract

With immunohistochemical and Western blot techniques, P2X1 receptors were detected in the whole mouse gastrointestinal tract and pancreatic islets of mouse and human. (1) δ Cells containing somatostatin (SOM) in the stomach corpus, small intestines, distal colon, pancreatic islets of both mouse and human express P2X1 receptors; (2) strong immunofluorescence of P2X1 receptors was detected in smooth muscle fibers and capillary networks of the villus core of mouse intestine; and (3) P2X1 receptor-immunoreactive neurons were also detected widely in both mouse myenteric and submucosal plexuses, all of which express SOM. The present data implies that ATP via P2X1 receptors is involved in SOM release from pancreatic δ cells, enteric neurons, and capillary networks in villi.

Indexed as

AnimalsGastrointestinal TractHumansIslets of LangerhansMiceMyenteric PlexusReceptors, Purinergic P2X1Somatostatin-Secreting CellsReceptors, Purinergic P2X1Gastrointestinal tractHumanMouseP2X1 receptorPancreatic islet

Identifiers

PMID29974392
PMCPMC6107460
OpenAlexW2809808745

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.