Evidence map›Paper›PMID 29974374›Full record

ArticleInflammation2018

p38 Inhibition Ameliorates Inspiratory Resistive Breathing-Induced Pulmonary Inflammation.

Dimitrios Toumpanakis, Vyronia Vassilakopoulou, Eleftheria Mizi, Athanasia Chatzianastasiou, Konstantinos Loverdos, Ioanna Vraila, Fotis Perlikos, Dionysios Tsoukalas, Charoula-Eleni Giannakopoulou, Adamantia Sotiriou and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Synergistic Effects of Resistive Breathing on Endotoxin-Induced Lung Injury in Mice.International journal of chronic obstructive pulmonary disease · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Dimitrios Toumpanakis1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Vyronia Vassilakopoulou1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Eleftheria Mizi1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Athanasia Chatzianastasiou1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Konstantinos Loverdos1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Ioanna Vraila1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Fotis Perlikos1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Dionysios Tsoukalas1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Charoula-Eleni Giannakopoulou1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Adamantia Sotiriou1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Maria Dettoraki1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Vassiliki Karavana1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece.
Theodoros Vassilakopoulos1st Department of Critical Care and Pulmonary Medicine and "Marianthi Simou" Applied Biomedical Research and Training Center, Medical School, Evangelismos Hospital, University of Athens, Athens, Greece. tvassil@med.uoa.gr.ORCID http://orcid.org/0000-0003-0254-8638
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inspiratory resistive breathing (IRB), a hallmark of obstructive airway diseases, is associated with strenuous contractions of the inspiratory muscles and increased negative intrathoracic pressures that act as an injurious stimulus to the lung. We have shown that IRB induces pulmonary inflammation in healthy animals. p38 kinase is activated in the lung under stress. We hypothesized that p38 is activated during IRB and contributes to IRB-induced pulmonary inflammation. Anesthetized, tracheostomized rats breathed spontaneously through a two-way valve. Resistance was connected to the inspiratory port to provoke a peak tidal inspiratory pressure 50% of maximum. Following 3 and 6 h of IRB, respiratory system mechanics were measured and bronchoalveolar lavage (BAL) was performed. Phosphorylated p38, TNF-α, and MIP-2α were detected in lung tissue. Lung injury was estimated histologically. SB203580 (p38 inhibitor) was administered prior to IRB (1 mg kg

Indexed as

InhalationAnimalsBronchoalveolar Lavage FluidChemokine CXCL2Enzyme InhibitorsImidazolesLung InjuryMacrophagesNeutrophilsp38 Mitogen-Activated Protein KinasesPneumoniaPyridinesRatsTumor Necrosis Factor-alphaChemokine CXCL2Enzyme InhibitorsImidazolesp38 Mitogen-Activated Protein KinasesPyridinesSB 203580Tumor Necrosis Factor-alphainflammationlungp38resistive breathing

Identifiers

PMID29974374
OpenAlexW2810670803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.