Evidence map›Paper›PMID 29974335›Full record

ArticleEJNMMI research2018

Discriminating radiation injury from recurrent tumor with [

Patrick L Donabedian, Susanne Kossatz, John A Engelbach, Stephen A Jannetti, Brandon Carney, Robert J Young, Wolfgang A Weber, Joel R Garbow, Thomas Reiner

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. [Journal of clinical medicine · 2024
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Novel Tracers and Radionuclides in PET Imaging.Radiologic clinics of North America · 2021
    Review
  10. Review
  11. Targeted Brain Tumor Radiotherapy Using an Auger Emitter.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  12. Article
  13. [Molecular imaging
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Patrick L DonabedianDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Susanne KossatzDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
John A EngelbachDepartment of Radiology, Washington University, St. Louis, MO, USA.
Stephen A JannettiDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Brandon CarneyDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Robert J YoungDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Wolfgang A WeberDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Joel R GarbowDepartment of Radiology, Washington University, St. Louis, MO, USA.
Thomas ReinerDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. reinert@mskcc.org.
Memorial Sloan Kettering Cancer Center · USWashington University in St. Louis · USCornell University · USHunter College · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Radioiodinated Multifunctional PARP1 Imaging Probes for Diagnosis and TherapyR01CA204441 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2016 to 2020
$2.9M
IMAGING BIOMARKERS FOR RADIATION-INDUCED NECROSISR01CA155365 · NCI · WASHINGTON UNIVERSITY · PI GARBOW, JOEL RICHARD · 2011 to 2015
$1.5M
National Cancer Institute R01 CA155365National Cancer Institute R01 CA204441NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA155365NCI NIH HHS R01 CA204441
6 · The paper itself

Abstract

backgroundRadiation injury can be indistinguishable from recurrent tumor on standard imaging. Current protocols for this differential diagnosis require one or more follow-up imaging studies, long dynamic acquisitions, or complex image post-processing; despite much research, the inability to confidently distinguish between these two entities continues to pose a significant dilemma for the treating clinician. Using mouse models of both glioblastoma and radiation necrosis, we tested the potential of poly(ADP-ribose) polymerase (PARP)-targeted PET imaging with [

resultsIn mice with experimental radiation necrosis, lesion uptake on [

conclusionsA murine model of radiation necrosis does not demonstrate [

Indexed as

Amino acid PETBiomarkersPARP1PET/CTRadiation injuryRadiation necrosis

Identifiers

PMID29974335
PMCPMC6031550
OpenAlexW2810477074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.