ReviewPituitary2018
Twelve cases of pituitary metastasis: a case series and review of the literature.
Review in Pituitary, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Current status and treatment modalities in metastases to the pituitary: a systematic review.Journal of neuro-oncology · 2020Pooled it
- Article
- Diabetes Insipidus as a Rare Complication of Metastatic Breast Cancer With Pituitary Metastases.Cureus · 2026Article
- Pituitary metastasis as an endocrine-neuro-ophthalmologic emergency: clinical red flags and outcomes from a contemporary tertiary-center series.Pituitary · 2026Article
- Clinical and imaging manifestations of metastases from rare sites.Quantitative imaging in medicine and surgery · 2026Review
- Malignant melanoma with pituitary metastasis: A case report and literature review.Frontiers in endocrinology · 2025Review
- Case Report: Pituitary metastasis from prostate adenocarcinoma: an integrated diagnosis viaFrontiers in medicine · 2025Article
- Article
- Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy.Reviews in endocrine & metabolic disorders · 2024Review
- Pituitary metastasis from lung adenocarcinoma: A case report.World journal of clinical cases · 2024Article
- Neuro-ophthalmological findings of pituitary metastasis: Case series from a single center and review of the literature.Heliyon · 2024Review
- An invasive nasopharyngeal carcinoma with extension to the pituitary gland mimicking an invasive pituitary macroadenoma: A case report.SAGE open medical case reports · 2024Article
- Metastases to the pituitary gland: insights from the German pituitary tumor registry.Pituitary · 2023Article
- Apoplexy in pituitary metastasis revealing a lung carcinoma.Respirology case reports · 2023Article
- Endoscopic Endonasal Surgery for Uncommon Pathologies of the Sellar and Parasellar Regions.Advances and technical standards in neurosurgery · 2023Review
- Diabetes Insipidus due to Metastases of Undiagnosed Lung Cancer: A Case Report from Syria.Case reports in endocrinology · 2023Article
- Masked diabetes insipidus in pituitary metastasis from breast cancer after thalamic biopsy: a case report.Journal of medical case reports · 2022Article
- Early and isolated breast cancer metastasis to the pituitary: A case report and systematic review.Surgical neurology international · 2022Article
- Case Report: Pituitary metastasis as a presenting manifestation of silent gastric cardia adenocarcinoma.Frontiers in oncology · 2022Article
- Evolution in endoscopic endonasal approach for the management of hypothalamic-pituitary region metastasis: A single-institution experience.Frontiers in oncology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe pituitary gland is an unusual site for metastatic spread, but as patients with metastatic malignancy are living longer, it may become more prevalent. Compression of important anatomy adjacent to the sella may produce disabling symptoms and endocrine derangement, leading to significant morbidity.
methodsAn ambispective review of patient records between 2013 and 2017 from three neurosurgical centres was performed. After identifying cases, further investigation was performed to evaluate patient demographic, symptoms at presentation, radiological and histological findings, management, and outcome.
resultsOur investigation identified 12 patients with pituitary metastasis. The average age of the cases was 63.4 years, with breast (n = 4) and lung (n = 4) being the most common primary cancers. In half the cases there was a history of metastatic disease, while in one-quarter of cases, pituitary symptoms were the first sign of malignancy. Adenohypophyseal dysfunction (83%), diabetes insipidus (DI) (75%), headache (67%) and visual field defects (67%) were the most common findings at presentation. Glucocorticoid replacement increased the sensitivity for diagnosis of DI. All cases were contrast enhancing on MRI and the endoscopic trans-sphenoidal approach was preferred for biopsy and debulking.
conclusionsThe pituitary should not be overlooked as a site of metastasis and sellar symptoms may be the first presentation of neoplastic disease. Any biochemical or clinical sign of pituitary pathology in a patient with known cancer should raise suspicion for sellar metastasis. Moreover, the development of DI or ophthalmoplegia from any pituitary lesion is suggestive of metastatic disease even in patients with no known primary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.