ArticleEuropean journal of nutrition2019
Diet as a moderator in the association of sedentary behaviors with inflammatory biomarkers among adolescents in the HELENA study.
Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Brazilian Children's Dietary Intake in Relation to Brazil's New Nutrition Guidelines: a Systematic Review.Current nutrition reports · 2019Pooled it
- Trial
- Association Between Daily Sitting Time and Urinary Leakage and the Double Mediation Effects of Inflammation and Physical Activity: A Cross-Sectional Study.International journal of women's health · 2026Article
- Association Between History of Gestational Diabetes Mellitus and the Risk of Urinary Leakage in Women: A Cross-Sectional Study.Health science reports · 2025Article
- Association between novel inflammatory biomarkers SII, SIRI, and obesity in sedentary adults: NHANES 2007-2020.Scientific reports · 2025Article
- Association of Dietary Fiber and Measures of Physical Fitness with High-Sensitivity C-Reactive Protein.Nutrients · 2024Article
- Association of Food Intake with Sleep Durations in Adolescents from a Capital City in Northeastern Brazil.Nutrients · 2022Article
- The Mediterranean Diet and the Western Diet in Adolescent Depression-Current Reports.Nutrients · 2022Review
- Use of the Dietary Inflammatory Index to Assess the Diet of Young Physically Active Men.International journal of environmental research and public health · 2022Article
- Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index.Frontiers in nutrition · 2022Article
- Inflammatory cytokine levels implicated in Alzheimer's disease moderate the effects of sex on verbal memory performance.Brain, behavior, and immunity · 2021Article
- The Perceived Impact of COVID-19 on Comfort Food Consumption over Time: The Mediational Role of Emotional Distress.Nutrients · 2021Article
- Homocysteine: Its Possible Emerging Role in At-Risk Population Groups.International journal of molecular sciences · 2020Review
- Cardiovascular Risk Factors and Haematological Indexes of Inflammation in Paralympic Athletes with Different Motor Impairments.Oxidative medicine and cellular longevity · 2019Article
- Does the Mediterranean Diet Protect against Stress-Induced Inflammatory Activation in European Adolescents? The HELENA Study.Nutrients · 2018Article
- Anti-Inflammatory and Pro-Inflammatory Adipokine Profiles in Children on Vegetarian and Omnivorous Diets.Nutrients · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 11 institutions in 9 countries.
Funding
Abstract
aimTo assess if a healthy diet might attenuate the positive sedentary-inflammation relation, whereas an unhealthy diet may increase the effect of sedentary behaviors on inflammatory biomarkers.
methodsIn 618 adolescents (13-17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake assessed by a self-administered computerized 24 h dietary recall for 2 days. A 9-point Mediterranean diet score and an antioxidant-rich diet z-score were used as dietary indices and tested as moderators. A set of low-grade inflammatory characteristics was used as outcome: several cytokines in an inflammatory ratio (IL-6, IL-10, TNF-α, TGFβ-1), C-reactive protein, three cell-adhesion molecules (sVCAM-1, sICAM-1, sE-selectin), three cardiovascular risk markers (GGT, ALT, homocysteine) and three immune cell types (white blood cells, lymphocytes, CD3). Sedentary behaviors were self-reported and analyzed as total screen time. Multiple linear regression analyses tested moderation by diet in the sedentary behaviors-inflammation association adjusted for age, sex, country, adiposity (sum of six skinfolds), parental education, and socio-economic status.
resultsBoth diet scores, Mediterranean and antioxidant-rich diet, were significant protective moderators in the effect of sedentary behaviors on alanine-transaminase enzyme (P = 0.014; P = 0.027), and on the pro/anti-inflammatory cytokine ratio (P = 0.001; P = 0.004), but not on other inflammatory parameters.
conclusionA higher adherence to the Mediterranean diet or an antioxidant-rich diet may attenuate the onset of oxidative stress signs associated by sedentary behaviors, whereas a poor diet seems to increase inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.