ArticleAnalytical and bioanalytical chemistry2018
Headspace analysis for screening of volatile organic compound profiles of electronic juice bulk material.
Article in Analytical and bioanalytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of secondhand smoke on air quality in partially enclosed outdoor hospitality venues: a review.BMC public health · 2024Pooled it
- Portable Spatially Offset Raman Spectroscopy for Rapid Detection of Methanol and Ethanol in Pisco Through Sealed Containers.Molecules (Basel, Switzerland) · 2026Article
- Review
- Evaluation of carbonyl collection methods in electronic cigarette aerosols.Frontiers in chemistry · 2025Article
- Thermal reaction products and formation pathways of two monoterpenes under in situ thermal desorption conditions that mimic vaping coil temperatures.Scientific reports · 2023Article
- Making Every Single Puff Count-Simple and Sensitive E-Cigarette Aerosol Sampling for GCxIMS and GC-MS Analysis.Molecules (Basel, Switzerland) · 2023Article
- In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice.Toxicological research · 2022Article
- Assessment of worker chemical exposures in California vape shops.Journal of occupational and environmental hygiene · 2022Article
- Model Predictions of Occupational Exposures to Diacetyl and 2,3-Pentanedione Emitted From Roasted Whole Bean and Ground Coffee: Influence of Roast Level and Physical Form on Specific Emission Rates.Frontiers in public health · 2022Article
- Effects of E-Cigarette Flavoring Chemicals on Human Macrophages and Bronchial Epithelial Cells.International journal of environmental research and public health · 2021Article
- Effect of Puffing Behavior on Particle Size Distributions and Respiratory Depositions From Pod-Style Electronic Cigarette, or Vaping, Products.Frontiers in public health · 2021Article
- A review of constituents identified in e-cigarette liquids and aerosols.Tobacco prevention & cessation · 2021Review
- Diacetyl and Other Ketones in e-Cigarette Aerosols: Some Important Sources and Contributing Factors.Frontiers in chemistry · 2021Article
- Modeled Respiratory Tract Deposition of Aerosolized Oil Diluents Used in ΔFrontiers in public health · 2021Article
- Major Constituents of Cannabis Vape Oil Liquid, Vapor and Aerosol in California Vape Oil Cartridge Samples.Frontiers in chemistry · 2021Article
- Method Validation Approaches for Analysis of Constituents in ENDS.Tobacco regulatory science · 2020Article
- Measuring e-cigarette addiction among adolescents.Tobacco control · 2020Article
- The Evolving E-cigarette: Comparative Chemical Analyses of E-cigarette Vapor and Cigarette Smoke.Frontiers in toxicology · 2020Article
- Adolescents' E-Cigarette Use: Increases in Frequency, Dependence, and Nicotine Exposure Over 12 Months.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2019Article
- Potential Hazards Not Communicated in Safety Data Sheets of Flavoring Formulations, Including Diacetyl and 2,3-Pentanedione.Annals of work exposures and health · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The use of electronic nicotine delivery systems continues to gain popularity, and there is concern for potential health risks from inhalation of aerosol and vapor produced by these devices. An analytical method was developed that provided quantitative and qualitative chemical information for characterizing the volatile constituents of bulk electronic cigarette liquids (e-liquids) using a static headspace technique. Volatile organic compounds (VOCs) were screened from a convenience sample of 146 e-liquids by equilibrating 1 g of each e-liquid in amber vials for 24 h at room temperature. Headspace was transferred to an evacuated canister and quantitatively analyzed for 20 VOCs as well as tentatively identified compounds using a preconcentrator/gas chromatography/mass spectrometer system. The e-liquids were classified into flavor categories including brown, fruit, hybrid dairy, menthol, mint, none, tobacco, and other. 2,3-Butanedione was found at the highest concentration in brown flavor types, but was also found in fruit, hybrid dairy, and menthol flavor types. Benzene was observed at concentrations that are concerning given the carcinogenicity of this compound (max 1.6 ppm in a fruit flavor type). The proposed headspace analysis technique coupled with partition coefficients allows for a rapid and sensitive prediction of the volatile content in the liquid. The technique does not require onerous sample preparation, dilution with organic solvents, or sampling at elevated temperatures. Static headspace screening of e-liquids allows for the identification of volatile chemical constituents which is critical for identifying and controlling emission of potentially hazardous constituents in the workplace.
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