ReviewFrontiers in cell and developmental biology2018
Cycling to Meet Fate: Connecting Pluripotency to the Cell Cycle.
Review in Frontiers in cell and developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Differential Biological and Molecular Profiling of Mesenchymal Progenitor Cells in Cartilage from Osteoarthritis and Rheumatoid Arthritis: An In Vitro Study.International journal of molecular sciences · 2026Article
- Development of a novel gene expression panel for the characterization of MSCs for increased biological safety.Journal of applied genetics · 2025Article
- Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration.Developmental cell · 2025Article
- Crosstalk between Signaling Pathways and Energy Metabolism in Pluripotency.International journal of stem cells · 2025Review
- Increased amounts of cell-free DNA released from a culture with a high content of cancer stem cells.Frontiers in cell and developmental biology · 2025Article
- Patient iPSC-derived neural progenitor cells display aberrant cell cycle control, p53, and DNA damage response protein expression in schizophrenia.BMC psychiatry · 2024Article
- Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration.bioRxiv : the preprint server for biology · 2024Article
- Cell cycle expression heterogeneity predicts degree of differentiation.Briefings in bioinformatics · 2024Article
- Cancer takes many paths through G1/S.Trends in cell biology · 2024Review
- Cell cycle expression heterogeneity predicts degree of differentiation.bioRxiv : the preprint server for biology · 2024Article
- Systematic mapping of TF-mediated cell fate changes by a pooled induction coupled with scRNA-seq and multi-omics approaches.Genome research · 2024Article
- Developmental progression continues during embryonic diapause in the roe deer.Communications biology · 2024Article
- Novel Strategy in Searching for Natural Compounds with Anti-Aging and Rejuvenating Potential.International journal of molecular sciences · 2023Article
- A gene subset requires CTCF bookmarking during the fast post-mitotic reactivation of mouse ES cells.EMBO reports · 2023Article
- The dynamical organization of the core pluripotency transcription factors responds to differentiation cues in early S-phase.Frontiers in cell and developmental biology · 2023Article
- Selective ablation of TRA-1-60Theranostics · 2023Article
- Transcription Factors STAT3 and MYC Are Key Players of Human Platelet Lysate-Induced Cell Proliferation.International journal of molecular sciences · 2022Article
- Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease.Genes · 2022Review
- Differential condensation of sister chromatids acts with Cdc6 to ensure asynchronous S-phase entry in Drosophila male germline stem cell lineage.Developmental cell · 2022Article
- Cell Death and the p53 Enigma During Mammalian Embryonic Development.Stem cells (Dayton, Ohio) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pluripotent stem cells are characterized by their high proliferative rates, their ability to self-renew and their potential to differentiate to all the three germ layers. This rapid proliferation is brought about by a highly modified cell cycle that allows the cells to quickly shuttle from DNA synthesis to cell division, by reducing the time spent in the intervening gap phases. Many key regulators that define the somatic cell cycle are either absent or exhibit altered behavior, allowing the pluripotent cell to bypass cell cycle checkpoints typical of somatic cells. Experimental analysis of this modified stem cell cycle has been challenging due to the strong link between rapid proliferation and pluripotency, since perturbations to the cell cycle or pluripotency factors result in differentiation. Despite these hurdles, our understanding of this unique cell cycle has greatly improved over the past decade, in part because of the availability of new technologies that permit the analysis of single cells in heterogeneous populations. This review aims to highlight some of the recent discoveries in this area with a special emphasis on different states of pluripotency. We also discuss the highly interlinked network that connects pluripotency factors and key cell cycle genes and review evidence for how this interdependency may promote the rapid cell cycle. This issue gains translational importance since disruptions in stem cell proliferation and differentiation can impact disorders at opposite ends of a spectrum, from cancer to degenerative disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.