Evidence map›Paper›PMID 29973936›Full record

ReviewFrontiers in immunology2018

Invariant Natural Killer T Cell Subsets-More Than Just Developmental Intermediates.

S Harsha Krovi, Laurent Gapin

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Discovery of Avian TCRVβ2European journal of immunology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. CD3Frontiers in immunology · 2025
    Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

S Harsha KroviDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Laurent GapinDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Funding

TCR signal strength and iNKT cell subset developmentR01AI130198 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GAPIN, LAURENT · 2018 to 2022
$1.9M
Regulation of Natural Killer T cell lineage diversification by the Src-like Adaptor protein 2R21AI124076 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GAPIN, LAURENT · 2016 to 2017
$422k
Inherent reactivity of T cell antigen receptors for MHC moleculesR21AI121761 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GAPIN, LAURENT · 2016 to 2017
$421k
NIAID NIH HHS R01 AI130198NIAID NIH HHS R21 AI121761NIAID NIH HHS R21 AI124076
6 · The paper itself

Abstract

Invariant natural killer T (iNKT) cells are a CD1d-restricted T cell population that can respond to lipid antigenic stimulation within minutes by secreting a wide variety of cytokines. This broad functional scope has placed iNKT cells at the frontlines of many kinds of immune responses. Although the diverse functional capacities of iNKT cells have long been acknowledged, only recently have distinct iNKT cell subsets, each with a marked functional predisposition, been appreciated. Furthermore, the subsets can frequently occupy distinct niches in different tissues and sometimes establish long-term tissue residency where they can impact homeostasis and respond quickly when they sense perturbations. In this review, we discuss the developmental origins of the iNKT cell subsets, their localization patterns, and detail what is known about how different subsets specifically influence their surroundings in conditions of steady and diseased states.

Indexed as

cytokine secretiondevelopmenthomeostasisinvariant natural killer T cellssubsets

Identifiers

PMID29973936
PMCPMC6019445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.