ArticleNature2018
The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8
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In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers.
0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed
22.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
182 citing papers in PubMed, 254 citations in OpenAlex.
- Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection.Science translational medicine · 2019Trial
- Mitochondrial Metabolic Reprogramming and Skin Immune Homeostasis: From Basic Mechanisms to Therapeutic Perspectives.Immune network · 2026Review
- CD8MedComm · 2026Review
- Regulatory T-cell Sensing of Extracellular ATP via P2RX7 Promotes Their Accumulation and Suppression and Drives Lung Tumor Growth.Cancer immunology research · 2026Article
- Cell intrinsic versus cell extrinsic control of plasma cell longevity.Trends in immunology · 2026Review
- KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Extracellular ATP Functions as a Metabolic Lineage Selection Signal That Stabilizes Tc9 Cells During Adoptive T Cell Therapy.International journal of molecular sciences · 2026Article
- Host-directed therapeutic strategies against apicomplexan parasites: targeting purinergic P2 receptors.Purinergic signalling · 2026Review
- The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs.Journal of advanced research · 2026Article
- Islet regeneration protein Reg3g promotes macrophage clearance of β cell-derived dysfunctional mitochondria-rich vesicles to mitigate T2DM.Redox biology · 2026Article
- Decoding signaling architectures: CAR versus TCR dynamics in solid tumor immunotherapy.Acta biochimica et biophysica Sinica · 2026Review
- Intestinal tissue-resident memory T cells: Characteristics, spatial heterogeneity, age-related dynamics, and roles in disease regulation.Journal of advanced research · 2026Review
- Fueling the sentinels: organelle remodeling and metabolic adaptation in tissue-resident memory T cell persistence.Frontiers in immunology · 2026Review
- P2X7 receptor: a potential therapeutic target for chronic respiratory diseases.Molecular and cellular biochemistry · 2026Review
- The role of gut microbiota in neuropathic pain: insights into immune mechanisms.The journal of headache and pain · 2025Review
- VNUT-mediated ATP release suppresses T helper 1 (TScience advances · 2025Article
- Trigeminal ganglion interferon-γ signaling drives orofacial neuropathic pain in rats.The journal of headache and pain · 2025Article
- Optimising Recovery of Hepatic Regulatory T Cells: A Practical Guide Using ARTC2 Blockade.European journal of immunology · 2025Article
- Bioorthogonal optimized virus immuno-nanomedicine (BOVIN).Nature communications · 2025Article
- eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Henrique Borges da SilvaCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Lalit K BeuraCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Haiguang WangCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Eric A HanseCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Reshma GoreDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Milcah C ScottCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Daniel A WalshCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Katharine E BlockCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Raissa FonsecaCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Yan YanCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Keli L HippenCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Bruce R BlazarCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
David MasopustCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Ameeta KelekarCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Lucy VulchanovaDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Kristin A HogquistCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Stephen C JamesonCenter for Immunology, University of Minnesota, Minneapolis, MN, USA. james024@umn.edu.
University of Minnesota · US
Funding
Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Mark J Osborn · 1995 to 2026
$48.2MTRAINING GRANT IN MICROBIOLOGY/CANCER RESEARCHT32CA009138 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Scott M. Dehm · 1985 to 2026
$11.3MNEUROSCIENCE TRAINING IN DRUG ABUSE RESEARCHT32DA007234 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Paul G Mermelstein, Jocelyn M Richard · 1986 to 2026
$10.9MEnhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7MT Cell HomeostasisR01AI038903 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN C JAMESON · 2001 to 2026
$5.9MIMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7MT-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4MPREDOCTORAL TRAINING OF NEUROSCIENTISTST32GM008471 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI EBNER, TIMOTHY J · 1993 to 2017
$4.9MGVL TO REDUCE AML RELAPSE AFTER MURINE ALLOGENEIC BMTR01CA072669 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1997 to 2017
$4.9MT cell homeostasisR37AI038903 · NIAID · UNIVERSITY OF MINNESOTA · PI JAMESON, STEPHEN C · 2006 to 2015
$3.6MT CELL TARGETING FOR GVHDR37HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R. · 1998 to 2007
$3.2MMinnesota Training Program in VirologyT32AI083196 · NIAID · UNIVERSITY OF MINNESOTA · PI Louis M Mansky · 2010 to 2026
$3.2MNCI NIH HHS P01 CA065493NCI NIH HHS R01 CA072669NCI NIH HHS R01 CA157971NCI NIH HHS T32 CA009138NHLBI NIH HHS R01 HL056067NHLBI NIH HHS R01 HL118979NHLBI NIH HHS R37 HL056067NIAID NIH HHS R01 AI038903NIAID NIH HHS R01 AI075168NIAID NIH HHS R29 AI038903NIAID NIH HHS R37 AI038903NIAID NIH HHS R56 AI075168NIAID NIH HHS T32 AI007313NIAID NIH HHS T32 AI083196NIDA NIH HHS T32 DA007234NIGMS NIH HHS T32 GM008471
Abstract
Extracellular ATP (eATP) is an ancient 'danger signal' used by eukaryotes to detect cellular damage
Indexed as
Immunologic MemoryAMP-Activated Protein KinasesAnimalsCD8-Positive T-LymphocytesCells, CulturedEnzyme ActivationFemaleHomeostasisHumansMiceMice, Inbred C57BLMitochondriaReceptors, Purinergic P2X7AMP-Activated Protein KinasesP2RX7 protein, humanP2rx7 protein, mouseReceptors, Purinergic P2X7
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.