ArticleThe American journal of gastroenterology2019
Non-Invasive Markers (ALBI and APRI) Predict Pregnancy Outcomes in Women With Chronic Liver Disease.
Article in The American journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- FIGO guideline on liver disease and pregnancy.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Guideline
- Pregnancy in Liver Cirrhosis: A Rare Clinical Case and Review of Current Management Strategies.Journal of clinical medicine · 2026Article
- The association of the ALBI score with disease severity and perinatal outcomes in the preeclampsia spectrum.BMC pregnancy and childbirth · 2026Article
- Impact of Liver Cirrhosis on Pregnancy Outcomes: A Retrospective Cohort Study from the TriNetX Global Collaborative Network.Medicina (Kaunas, Lithuania) · 2026Article
- Preexisting Liver Disease and Pregnancy: Optimizing Care to Optimize Outcomes.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Review
- Diagnostic and prognostic value of transaminase complex-platelet ratio in intrahepatic cholestasis of pregnancy: A novel composite index based on routine blood tests.Turkish journal of obstetrics and gynecology · 2025Article
- Unmet needs in autoimmune liver diseases.Current opinion in immunology · 2025Review
- Pregnancy Outcomes in Women With Liver Cirrhosis: A National Prospective Cohort Study Using the UK Obstetric Surveillance System.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Non-invasive strategies to predict post-hepatectomy liver failure.Hepatobiliary surgery and nutrition · 2024Article
- Liver imaging and pregnancy: what to expect when your patient is expecting.Insights into imaging · 2024Review
- Aspartate Aminotransferase/Platelet Ratio Index Upon Admission Predicts 24-Week Mortality in Patients With HIV-AssociatedOpen forum infectious diseases · 2023Article
- Cirrhosis in pregnancy.Clinical liver disease · 2023Article
- Maternal and Perinatal Outcome in a Contemporary Cohort of Patients with Portal Hypertension: A Single-Center Experience.Journal of clinical medicine · 2023Article
- British Society of Gastroenterology Best Practice Guidance: outpatient management of cirrhosis - part 3: special circumstances.Frontline gastroenterology · 2023Article
- Development of obstetric-hepatology services: defining optimal care and impact of pregnancy counselling on patient experience.Frontline gastroenterology · 2023Article
- Pregnancy Is Not Associated with an Increased Risk of Decompensation, Transplant, or Death in Compensated Cirrhosis.International journal of hepatology · 2022Article
- Maternal and fetal outcomes of patients with liver cirrhosis: a case-control study.BMC pregnancy and childbirth · 2021Article
- Management of pregnancy in women with cirrhosis.United European gastroenterology journal · 2021Review
- A novel online calculator based on albumin-bilirubin and aspartate transaminase-to-platelet ratio index for predicting postoperative morbidity following hepatectomy for hepatocellular carcinoma.Annals of translational medicine · 2020Article
- Liver Disease in Pregnancy: What's New.Hepatology communications · 2020Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRates of pregnancy in women with cirrhosis are increasing. Risk of hepatic decompensation during pregnancy, therefore, merits tailored obstetric and hepatology care. Prognostic markers that determine pregnancy outcomes are lacking.
methodsMedical records of women who attended hepatology clinic at King's College Hospital with chronic liver disease (CLD) who became pregnant from 1983 to 2017 were reviewed. Information on demographics, clinical history, serology, and outcome of pregnancy was collected.
resultsIn all, 165 pregnancies occurred in 100 women with CLD including 80 pregnancies in 48 women with cirrhosis. Median age of conception in cirrhotic and non-cirrhotic women were 26 years (16-44) and 28 years (16-51) respectively (p = 0.015). Whilst women with cirrhosis had similar live birth rate to non-cirrhotic women (75 vs. 85% p = 0.119), they were significantly less likely to proceed beyond 37 weeks gestation (45 vs. 58% p = 0.033). Women who received preconception counseling were more likely to have stable liver disease at conception (100 vs 86% p = 0.02). Compared with preconception MELD (model for end stage liver disease), preconception Albumin-Bilirubin score (ALBI) more accurately predicted live birth with an area under the receiver-operator curve (AUROC) of 0.741 (p < 0.001), and preconception AST to platelet ratio index (APRI) more accurately predicted ability to proceed beyond 37 weeks gestation with an AUROC of 0.700 (p < 0.001).
conclusionsMost women with cirrhosis who conceived achieved a successful pregnancy outcome. ALBI and APRI scores can prognosticate pregnancy outcomes in women with CLD. Preconception counseling by a hepatologist or specialist obstetrician improved patient care in this group.
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