ArticleScientific reports2018
Gene expression profile in peripheral blood mononuclear cells of postpartum depression patients.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Systematic review and meta-analysis of the relationship between sleep disorders and suicidal behaviour in patients with depression.BMC psychiatry · 2019Pooled it
- Time series analysis of anxiety and depression during pregnancy to postpartum depression based on cross-lagged model.World journal of psychiatry · 2026Article
- Progress and challenges in exploring the pathogenesis of depressive disorders via RNA sequencing.Frontiers in genetics · 2026Review
- Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum.Molecular psychiatry · 2025Article
- Exploring Gut Microbe-Host Genes in Postpartum Depression: Mendelian Randomization and Transcriptomic Analysis.International journal of women's health · 2025Article
- Inflammatory signaling pathways in the treatment of Alzheimer's disease with inhibitors, natural products and metabolites (Review).International journal of molecular medicine · 2023Review
- Intrinsically dysregulated cellular stress signaling genes and gene networks in postpartum depression.Molecular psychiatry · 2023Article
- Article
- Mitochondrial might: powering the peripartum for risk and resilience.Frontiers in behavioral neuroscience · 2023Review
- The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis - preliminary report.Archives of medical science : AMS · 2023Article
- Cellular and immunometabolic mechanisms of inflammation in depression: Preliminary findings from single cell RNA sequencing and a tribute to Bruce McEwen.Neurobiology of stress · 2022Article
- Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance.Molecular psychiatry · 2022Article
- Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications.Pharmacological reviews · 2021Review
- Postpartum Depression: Current Status and Possible Identification Using Biomarkers.Frontiers in psychiatry · 2021Review
- The BDNF-FoxO1 Axis in the medial prefrontal cortex modulates depressive-like behaviors induced by chronic unpredictable stress in postpartum female mice.Molecular brain · 2020Article
- Pregnancy, postpartum and parity: Resilience and vulnerability in brain health and disease.Frontiers in neuroendocrinology · 2020Review
- Identification of key genes, pathways, and miRNA/mRNA regulatory networks of CUMS-induced depression in nucleus accumbens by integrated bioinformatics analysis.Neuropsychiatric disease and treatment · 2019Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postpartum depression (PPD) is a common mental health problem that causes maternal suffering and various negative consequences for offspring. The pathogenesis of PPD and the causes of consequences for offspring remain largely unknown. Here, we applied RNA sequencing to sequence the whole transcriptomes of peripheral blood mononuclear cells (PBMCs) from PPD patients (Edinburgh Postnatal Depression Scale [EPDS] score ≥13) and control subjects (EPDS = 0). We found that PPD was positively correlated with multiple genes involved in energy metabolism, neurodegenerative diseases and immune response, while negatively correlated with multiple genes in mismatch repair and cancer-related pathways. Remarkably, genes associated with appetite regulation and nutrient response were differentially expressed between PPD and control subjects. Then, we employed a postnatal growth retardation model by repeated immobilization stress (IS) stimulation to maternal mice. The expression of appetite regulation and nutrient response-related genes in the PBMCs of IS mice and in the hypothalamus of their offspring were also affected. In conclusion, this study provides a comprehensive characterization of the PBMCs transcriptome in PPD and suggests that maternal stress may affect appetite regulation and nutrient response in the hypothalamus of offspring mice.
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