Evidence map›Paper›PMID 29973643›Full record

ArticleScientific reports2018

Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells.

Han-Dong Sun, Zhi-Peng Xu, Zhi-Qiang Sun, Bin Zhu, Qian Wang, Jian Zhou, Hui Jin, Andi Zhao, Wei-Wei Tang, Xiu-Feng Cao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Circular RNAs and Cancers.Advances in experimental medicine and biology · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Overview of mJournal of cancer research and clinical oncology · 2023
    Review
  11. Review
  12. The Tumorigenic Role of Circular RNA-MicroRNA Axis in Cancer.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Role of main RNA modifications in cancer: NSignal transduction and targeted therapy · 2022
    Review
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Han-Dong SunDepartment of Oncology Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Zhi-Peng XuDepartment of Oncology Surgery, Nanjing SIR RUN RUN Hospital, Nanjing Medical University, Nanjing, China.
Zhi-Qiang SunNanjing Medical University School of Pharmacy, Nanjing, China.
Bin ZhuDepartment of Oncology Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Qian WangDepartment of Oncology Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Jian ZhouDepartment of Oncology Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Hui JinDepartment of Hematology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, China.ORCID 0000-0003-0297-3052
Andi ZhaoDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Wei-Wei TangDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. 1243773473twww@sina.com.
Xiu-Feng CaoDepartment of Oncology Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. cxf551101@sina.com.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA (circRNA) is a key regulator in the development and progression of various types of carcinomas. However, its role in gastric cancer (GC) tumorigenesis is not well understood. The present study aimed to investigate the expression profile and potential modulation of circRNAs on GC carcinogenesis. Human circRNA microarray was performed to screen for abnormally expressed circRNA in GC tissue. Results showed that a decrease in the circPVRL3 expression level was associated with the presence of GC, and also with higher TNM stage and lower overall survival rates compared with that in adjacent noncancerous tissues. In vitro assays of the GC cell lines MKN-45 and MGC-803 demonstrated that knockdown of circPVRL3 promoted cell proliferation significantly. Prediction and annotation revealed circPVRL3 was able to sponge to 9 miRNAs and may be also able to have a binding with AGO2, FUS, LIN28A, PTB, and EIF4A3. In addition, based on the structure of internal ribosomal entry sites, open reading frame, and m

Indexed as

Cell MovementCell ProliferationDown-RegulationArgonaute ProteinsCarcinomaCell Line, TumorDEAD-box RNA HelicasesEukaryotic Initiation Factor-4AFemaleGene Expression Regulation, NeoplasticHumansMaleMicroRNAsMiddle AgedRNARNA-Binding Protein FUSAGO2 protein, humanArgonaute ProteinsDEAD-box RNA HelicasesEIF4A3 protein, humanEukaryotic Initiation Factor-4AFUS protein, humanLIN28B protein, humanMicroRNAsRNARNA-Binding Protein FUSRNA-Binding ProteinsRNA, Circular

Identifiers

PMID29973643
PMCPMC6031698
OpenAlexW2810578662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.