Evidence map›Paper›PMID 29973582›Full record

ArticleNature communications2018

Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy.

Zhen Fan, Yan Chang, Chaochu Cui, Leming Sun, David H Wang, Zui Pan, Mingjun Zhang

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 148 citations in OpenAlex.

  1. Review
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  7. Holothurian triterpene glycoside cucumarioside ACancer cell international · 2023
    Article
  8. Article
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  11. Peptide Self-Assembled Nanocarriers for Cancer Drug Delivery.The journal of physical chemistry. B · 2023
    Review
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  15. Strategic Approaches to Improvise Peptide Drugs as Next Generation Therapeutics.International journal of peptide research and therapeutics · 2023
    Review
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Zhen FanDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Yan ChangCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX, 76019, USA.
Chaochu CuiCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX, 76019, USA.
Leming SunSchool of Life Sciences, Northwestern Polytechnical University, 710065, Xi'an, China.
David H WangDepartment of Internal Medicine, Esophageal Diseases Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Zui PanCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX, 76019, USA. zui.pan@uta.edu.ORCID http://orcid.org/0000-0003-4105-901X
Mingjun ZhangDepartment of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, OH, 43210, USA. zhang.4882@osu.edu.
The University of Texas at Arlington · USNorthwestern Polytechnical University · CNSun Yat-sen University · CNThe Ohio State University Wexner Medical Center · USTongji University · CNVA North Texas Health Care System · US

Funding

Oncogenic Function of Ca2+ Channel Orai1 in Esophageal CarcinogenesisR01CA185055 · NCI · OHIO STATE UNIVERSITY · PI CHEN, TONG, PAN, ZUI · 2015 to 2019
$1.6M
Cyclic Peptide Nanoparticles Based Dual-drug Delivery to Treat Prostate CancerR01CA226251 · NCI · OHIO STATE UNIVERSITY · PI ZHANG, MINGJUN · 2018 to 2018
$456k
NCI NIH HHS R01 CA185055NCI NIH HHS R01 CA226251NIH HHS R01-CA226251
6 · The paper itself

Abstract

Various types of nanoparticles have been proposed for targeted drug delivering, imaging, and tracking of therapeutic agents. However, highly biocompatible nanoparticles with structure-induced fluorescence and capability to conjugate with biomarkers and drugs remain lacking. This research proposes and synthesizes fluorescent nanoparticles (f-PNPs) assembled by cyclic peptides to combine imaging and drug delivering for esophageal cancer (EC). To achieve tumor targeting, f-PNPs are first conjugated with RGD moieties to selectively target EC cells via α

Indexed as

AnimalsAntibiotics, AntineoplasticCell Line, TumorDrug CompoundingDrug Delivery SystemsDrug MonitoringEpirubicinEsophageal NeoplasmsFluorescenceHumansInjections, IntraperitonealIntegrin alphaVbeta3MaleMiceMice, NudeMolecular ImagingAntibiotics, Antineoplasticarginyl-glycyl-aspartic acidEpirubicinIntegrin alphaVbeta3OligopeptidesPeptides, Cyclic

Identifiers

PMID29973582
PMCPMC6031624
OpenAlexW2809987360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.