Evidence map›Paper›PMID 29973540›Full record

ArticleInternational journal of molecular sciences2018

Time Dependent Pathway Activation of Signalling Cascades in Rat Organs after Short-Term Hyperoxia.

Jochen Hinkelbein, Stefan Braunecker, Matthias Danz, Lennert Böhm, Andreas Hohn

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Constitutive transgenic α-Klotho overexpression enhances resilience to and recovery from murine acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jochen HinkelbeinDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, 50937 Cologne, Germany. jochen.hinkelbein@uk-koeln.de.
Stefan BrauneckerDepartment of Anaesthesiology, St George's University Hospital, NHS Foundation Trust, London SW17 0QT, UK. stefan.braunecker@nhs.net.ORCID 0000-0003-3095-764X
Matthias DanzDepartment of Anesthesiology, St. Martinus Hospital, 57462 Olpe, Germany. matthias.danz@gmx.de.
Lennert BöhmEmergency Department, University of Duesseldorf, 40225 Düsseldorf, Germany. lennert.boehm@gmx.de.
Andreas HohnDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, 50937 Cologne, Germany. jochen.hinkelbein@uk-koeln.de.
University Hospital Cologne · DEHeinrich Heine University Düsseldorf · DESt George’s University Hospitals NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Administration of oxygen is one of the most common interventions in medicine. Previous research showed that differential regulated proteins could be linked to hyperoxia-associated signaling cascades in different tissues. However, it still remains unclear which signaling pathways are activated by hyperoxia. The present study analyses hyperoxia-induced protein alterations in lung, brain, and kidney tissue using a proteomic and bioinformatic approach. Pooled data of 36 Wistar rats exposed to hyperoxia were used. To identify possible hyperoxia biomarkers, and to evaluate the relationship between protein alterations in hyperoxia affected organs and blood, proteomics data from brain, lung, and kidney were analyzed. Functional network analyses (IPA

Indexed as

AnimalsApoptosisBiomarkersBrainCell DeathDatabases, ProteinHumansHyperoxiaKidneyLungOxidative StressOxygenProteinsProteomicsRatsRats, WistarBiomarkersOxygenProteinshyperoxiaoxygenprotein expressionproteomicssignaling cascades

Identifiers

PMID29973540
PMCPMC6073502
OpenAlexW2810537808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.