ReviewOpen biology2018
On the networked architecture of genotype spaces and its critical effects on molecular evolution.
Review in Open biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Constrained Diffusion as a Paradigm for Evolution.bioRxiv : the preprint server for biology · 2026Article
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Traces of a Primitive RNA Ring in Current Genomes.Biology · 2025Article
- Fundamental constraints to the logic of living systems.Interface focus · 2024Review
- Physics of diffusion in viral genome evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- On the origin of life: an RNA-focused synthesis and narrative.RNA (New York, N.Y.) · 2023Article
- The non-deterministic genotype-phenotype map of RNA secondary structure.Journal of the Royal Society, Interface · 2023Article
- Not Quite Lost in Translation: Mistranslation Alters Adaptive Landscape Topography and the Dynamics of Evolution.Molecular biology and evolution · 2023Article
- Robustness and innovation in synthetic genotype networks.Nature communications · 2023Article
- The ensemble of gene regulatory networks at mutation-selection balance.Journal of the Royal Society, Interface · 2023Article
- Life finds a way.Nature ecology & evolution · 2022Article
- Getting higher on rugged landscapes: Inversion mutations open access to fitter adaptive peaks in NK fitness landscapes.PLoS computational biology · 2022Article
- A Family of Fitness Landscapes Modeled through Gene Regulatory Networks.Entropy (Basel, Switzerland) · 2022Article
- Neutral components show a hierarchical community structure in the genotype-phenotype map of RNA secondary structure.Journal of the Royal Society, Interface · 2020Article
- Mutation bias interacts with composition bias to influence adaptive evolution.PLoS computational biology · 2020Article
- Using small samples to estimate neutral component size and robustness in the genotype-phenotype map of RNA secondary structure.Journal of the Royal Society, Interface · 2020Article
- Article
- Epistasis between cultural traits causes paradigm shifts in cultural evolution.Royal Society open science · 2020Article
- Taming out-of-equilibrium dynamics on interconnected networks.Nature communications · 2019Article
- Every which way? On predicting tumor evolution using cancer progression models.PLoS computational biology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolutionary dynamics is often viewed as a subtle process of change accumulation that causes a divergence among organisms and their genomes. However, this interpretation is an inheritance of a gradualistic view that has been challenged at the macroevolutionary, ecological and molecular level. Actually, when the complex architecture of genotype spaces is taken into account, the evolutionary dynamics of molecular populations becomes intrinsically non-uniform, sharing deep qualitative and quantitative similarities with slowly driven physical systems: nonlinear responses analogous to critical transitions, sudden state changes or hysteresis, among others. Furthermore, the phenotypic plasticity inherent to genotypes transforms classical fitness landscapes into multiscapes where adaptation in response to an environmental change may be very fast. The quantitative nature of adaptive molecular processes is deeply dependent on a network-of-networks multilayered structure of the map from genotype to function that we begin to unveil.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.