ArticleBMC infectious diseases2018
Extra-haematological manifestations related to human parvovirus B19 infection: retrospective study in 25 adults.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Human parvovirus B19-associated Guillain-Barré syndrome diagnosed by cerebrospinal fluid targeted next-generation sequencing: a case report and literature review.BMC infectious diseases · 2026Review
- Multiple Mononeuropathy Secondary to Parvovirus B19 Infection: A Case Series.European journal of neurology · 2026Observational
- Cryoglobulinaemic Vasculitis Secondary to Parvovirus B19 Infection: A Case-Based Review.Mediterranean journal of rheumatology · 2025Article
- Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.Biochimica et biophysica acta. Molecular basis of disease · 2021Review
- Renal infarction and papular-purpuric gloves and socks syndrome (PPGSS): rare extra-haematological manifestations of acute parvovirus B-19 infection.BMJ case reports · 2021Article
- Importance of the hematology laboratory in infectious disease diagnosis by morphology: Four educational case studies.International journal of laboratory hematology · 2020Article
- Acute parvovirus B19 infection presenting as rheumatoid arthritis mimic.Journal of family medicine and primary care · 2019Article
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Authors and funding
17 authors at 15 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo describe extra-haematological manifestations associated with human parvovirus B19 (HPV-B19) infection.
methodsWe conducted a nationwide multicentre study to retrospectively describe the characteristics and outcome of extra-haematological manifestations in French adults.
resultsData from 25 patients followed from 2001 to 2016 were analysed. Median age was 37.9 years (range: 22.7-83.4), with a female predominance (sex ratio: 4/1). Only 3 patients had an underlying predisposing condition (hemoglobinopathy or pregnancy). The most common manifestations were joint (80%) and skin (60%) involvement. Four patients (16%) had renal involvement (endocapillary proliferative or membranoproliferative glomerulonephritis, focal segmental glomerulosclerosis). Three patients (12%) had peripheral nervous system involvement (mononeuritis, mononeuritis multiplex, Guillain-Barré syndrome) and 2 (8%) presented muscle involvement. Other manifestations included hemophagocytic lymphohistiocytosis (n = 1), myopericarditis and pleural effusion (n = 1), and lymphadenopathy and splenomegaly mimicking lymphoma with spleen infarcts (n = 1). Immunological abnormalities were frequent (56.5%). At 6 months, all patients were alive, and 54.2% were in complete remission. In 2 patients, joint involvement evolved into rheumatoid arthritis. Six patients (24%) received intravenous immunoglobulin (IVIg), with a good response in the 3 patients with peripheral nervous system involvement.
conclusionsHPV-B19 infection should be considered in a wide range of clinical manifestations. Although the prognosis is good, IVIg therapy should be discussed in patients with peripheral nerve involvement. However, its efficacy should be further investigated in prospective studies.
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