ArticleBMC genomics2018
Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Granaticin biosynthesis and engineering: mechanistic understanding, production bottlenecks, and computational opportunities.World journal of microbiology & biotechnology · 2026Review
- Computational analysis into the potential of azo dyes as a feedstock for actinorhodin biosynthesis in Pseudomonas putida.PloS one · 2024Article
- Flux balance analysis-based metabolic modeling of microbial secondary metabolism: Current status and outlook.PLoS computational biology · 2023Review
- A Holistic Approach from Systems Biology Reveals the Direct Influence of the Quorum-Sensing Phenomenon onMetabolites · 2023Article
- Construction and application of the genome-scale metabolic model ofFrontiers in bioengineering and biotechnology · 2023Article
- Article
- Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A.mSystems · 2021Article
- Synthetic biology approaches to actinomycete strain improvement.FEMS microbiology letters · 2021Review
- Clavulanic Acid Production byAntibiotics (Basel, Switzerland) · 2021Review
- Comparative Transcriptome Analysis ofFrontiers in bioengineering and biotechnology · 2020Article
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Authors and funding
3 authors.
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Abstract
backgroundStreptomyces species produce a vast diversity of secondary metabolites of clinical and biotechnological importance, in particular antibiotics. Recent developments in metabolic engineering, synthetic and systems biology have opened new opportunities to exploit Streptomyces secondary metabolism, but achieving industry-level production without time-consuming optimization has remained challenging. Genome-scale metabolic modelling has been shown to be a powerful tool to guide metabolic engineering strategies for accelerated strain optimization, and several generations of models of Streptomyces metabolism have been developed for this purpose.
resultsHere, we present the most recent update of a genome-scale stoichiometric constraint-based model of the metabolism of Streptomyces coelicolor, the major model organism for the production of antibiotics in the genus. We show that the updated model enables better metabolic flux and biomass predictions and facilitates the integrative analysis of multi-omics data such as transcriptomics, proteomics and metabolomics.
conclusionsThe updated model presented here provides an enhanced basis for the next generation of metabolic engineering attempts in Streptomyces.
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