ReviewBiophysical journal2018
Do Cellular Condensates Accelerate Biochemical Reactions? Lessons from Microdroplet Chemistry.
Review in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Article
- Biomolecular condensates can function as inherent catalysts.Molecular cell · 2026Article
- Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.bioRxiv : the preprint server for biology · 2026Article
- Biomolecular condensates provide a unique environment for redox-mediated protein crosslinking.bioRxiv : the preprint server for biology · 2026Article
- The Formation of Covalent Linkages in Lignocellulosic Biomass via the Oxocarbenium Intermediate.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Liquid Crystal-Driven Chemical Feeding Accelerates Condensation Reactions in Droplet Microreactors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Material properties of biomolecular condensates emerge from nanoscale dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Condenzymes: Biomolecular condensates with inherent catalytic activities.bioRxiv : the preprint server for biology · 2025Article
- Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates.Nature communications · 2025Article
- The mechanobiology of biomolecular condensates.Biophysics reviews · 2025Review
- Article
- How Droplets Can Accelerate Reactions─Coacervate Protocells as Catalytic Microcompartments.Accounts of chemical research · 2024Article
- Article
- Femtoliter oil droplets act as COJournal of colloid and interface science · 2024Article
- The Burgeoning Significance of Liquid-Liquid Phase Separation in the Pathogenesis and Therapeutics of Cancers.International journal of biological sciences · 2024Review
- Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions.Nature communications · 2023Article
- Phase Transitions of Associative Biomacromolecules.Chemical reviews · 2023Review
- Biomolecular condensates - extant relics or evolving microcompartments?Communications biology · 2023Review
- Phase Separation in Mixtures of Prion-Like Low Complexity Domains is Driven by the Interplay of Homotypic and Heterotypic Interactions.Research square · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Cellular condensates-phase-separated concentrates of proteins and nucleic acids-provide organizational structure for biochemistry that is distinct from membrane-bound compartments. It has been suggested that one major function of cellular condensates is to accelerate biochemical processes that are normally slow or thermodynamically unfavorable. Yet, the mechanisms leading to increased reaction rates within cellular condensates remain poorly understood. In this article, we highlight recent advances in microdroplet chemistry that accelerate reaction rates by many orders of magnitude as compared to bulk and suggest that similar mechanisms may also affect reaction kinetics in cellular condensates.
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