Evidence map›Paper›PMID 29972798›Full record

ArticleCell metabolism2018

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling.

Ming Luo, Li Shang, Michael D Brooks, Evelyn Jiagge, Yongyou Zhu, Johanna M Buschhaus, Sarah Conley, Melissa A Fath, April Davis, Elizabeth Gheordunescu and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 2 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 2 syntheses or guidelines pooled it, 360 citations in OpenAlex.

  1. Pooled it
  2. PGC1α-Mediated Metabolic Reprogramming Drives the Stemness of Pancreatic Precursor Lesions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Pooled it
  3. Significance of GSH and HRedox report : communications in free radical research · 2026
    Review
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154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Ming LuoDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mingluo@med.umich.edu.
Li ShangDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Michael D BrooksDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Evelyn JiaggeDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Yongyou ZhuDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Johanna M BuschhausCenter of Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Sarah ConleyDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Melissa A FathFree Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA.
April DavisDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Elizabeth GheordunescuDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Yongfang WangDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Ramdane HarouakaDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Ann LozierDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Daniel TrinerDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Sean McDermottDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Sofia D MerajverDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Gary D LukerCenter of Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Douglas R SpitzFree Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA.
Max S WichaDepartment of Internal Medicine, Division of Hematology & Oncology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mwicha@med.umich.edu.
University of Michigan–Ann Arbor · USUniversity of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Mark E Burkard · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5M
Targeting breast cancer stem cellsR35CA197585 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WICHA, MAX S. · 2016 to 2022
$6.4M
Environmental Regulation of Cancer Stem Cell Plasticity in MetastasisU01CA210152 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAHANN, JOERG, LUKER, GARY D · 2017 to 2021
$3.6M
Regulation of Breast Stem Cells by the MicroenvironmentR01CA101860 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WICHA, MAX S. · 2004 to 2013
$2.4M
Systems Bioengineering of Cancer Cell MigrationR01CA196018 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LINDERMAN, JENNIFER JEAN, LUKER, GARY D · 2015 to 2019
$2.2M
Enhancing Metabolic Oxidative Stress and Therapy Responses in Cancer Stem CellsR01CA182804 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 2014 to 2018
$1.7M
NCI NIH HHS P30 CA086862NCI NIH HHS R01 CA101860NCI NIH HHS R01 CA182804NCI NIH HHS R01 CA196018NCI NIH HHS R35 CA197585NCI NIH HHS U01 CA210152NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Although breast cancer stem cells (BCSCs) display plasticity transitioning between quiescent mesenchymal-like (M) and proliferative epithelial-like (E) states, how this plasticity is regulated by metabolic or oxidative stress remains poorly understood. Here, we show that M- and E-BCSCs rely on distinct metabolic pathways and display markedly different sensitivities to inhibitors of glycolysis and redox metabolism. Metabolic or oxidative stress generated by 2DG, H

Indexed as

Cell Transformation, NeoplasticAcetylcysteineAMP-Activated Protein Kinase KinasesAnimalsAntioxidantsBreast NeoplasmsCell Line, TumorFemaleGlucoseGlutathioneGlycolysisHumansMice, Inbred NODNeoplastic Stem CellsNF-E2-Related Factor 2Oxidation-ReductionAcetylcysteineAMP-Activated Protein Kinase KinasesAntioxidantsGlucoseGlutathioneNFE2L2 protein, humanNF-E2-Related Factor 2Protein KinasesReactive Oxygen SpeciesThioredoxinsantioxidant responsescancer stem cell metabolismcancer stem cell plasticityglycolysisHIF1αhypoxiaNRF2oxidative phosphorylation

Identifiers

PMID29972798
PMCPMC6037414
OpenAlexW2810028506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.