ArticleCell reports2018
Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Tbx16 and mesogenin 1 promote presomitic mesoderm differentiation by repressing the mesodermal progenitor cell state.PLoS genetics · 2026Article
- Unravelling the progression of the zebrafish primary body axis with reconstructed spatiotemporal transcriptomics.Genome biology · 2026Article
- Evolvability in vertebrate segmentation.Seminars in cell & developmental biology · 2025Review
- Formation control between leader and migratory follower tissues allows coordinated growth.Science advances · 2025Article
- Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis.Development (Cambridge, England) · 2025Article
- Article
- DeltaC and DeltaD ligands play different roles in the segmentation clock dynamics.Nature communications · 2025Article
- The vertebrate segmentation clock drives segmentation by stabilizing Dusp phosphatases in zebrafish.Developmental cell · 2025Article
- Article
- A human pluripotent stem cell-based somitogenesis model using microfluidics.Cell stem cell · 2024Article
- Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024Review
- An emerging role for tissue plasticity in developmental precision.Biochemical Society transactions · 2024Review
- Oscillatory control of embryonic development.Development (Cambridge, England) · 2024Review
- Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis.bioRxiv : the preprint server for biology · 2024Article
- Spatiotemporal control of pattern formation during somitogenesis.Science advances · 2024Review
- A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut.Development (Cambridge, England) · 2023Article
- A design logic for sequential segmentation across organisms.The FEBS journal · 2023Article
- Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes.Nature communications · 2023Article
- The Role of Fibroblast Growth Factor Signaling in Somitogenesis.DNA and cell biology · 2023Review
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Signal gradients encode instructive information for numerous decision-making processes during embryonic development. A striking example of precise, scalable tissue-level patterning is the segmentation of somites-the precursors of the vertebral column-during which the fibroblast growth factor (FGF), Wnt, and retinoic acid (RA) pathways establish spatial gradients. Despite decades of studies proposing roles for all three pathways, the dynamic feature of these gradients that encodes instructive information determining segment sizes remained elusive. We developed a non-elongating tail explant system, integrated quantitative measurements with computational modeling, and tested alternative models to show that positional information is encoded solely by spatial fold change (SFC) in FGF signal output. Neighboring cells measure SFC to accurately position the determination front and thus determine segment size. The SFC model successfully recapitulates results of spatiotemporal perturbation experiments on both explants and intact embryos, and it shows that Wnt signaling acts permissively upstream of FGF signaling and that RA gradient is dispensable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.