ArticleDiabetes/metabolism research and reviews2018
Explanations for less small fibre neuropathy in South Asian versus European subjects with type 2 diabetes in the UK.
Article in Diabetes/metabolism research and reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
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- Heterogeneity in the development of diabetes-related complications: narrative review of the roles of ancestry and geographical determinants.Diabetologia · 2025Review
- Methods for the evaluation of corneal nerve fibres in diabetes mellitus by in vivo confocal microscopy: a scoping review.BMJ open · 2025Article
- Corneal Nerve Morphology in Painful Diabetic Neuropathy: A Meta-Analysis of In Vivo Confocal Microscopy Studies.Biomedicines · 2025Review
- Clinical and Electrophysiological Characterization of Diabetic Neuropathy in a Sub-Saharan African Cohort.Journal of the peripheral nervous system : JPNS · 2025Article
- Ethnic and sex differences in corneal nerves and corneal epithelial cells in healthy population.Frontiers in medicine · 2025Article
- Glycemic variability's impact on painful diabetic peripheral neuropathy in type 2 diabetes patients.Scientific reports · 2024Article
- Corneal nerves and amyotrophic lateral sclerosis: an in vivo corneal confocal imaging study.Journal of neurology · 2024Article
- Is Nerve Electrophysiology a Robust Primary Endpoint in Clinical Trials of Treatments for Diabetic Peripheral Neuropathy?Diagnostics (Basel, Switzerland) · 2022Review
- Corneal nerve loss in patients with TIA and acute ischemic stroke in relation to circulating markers of inflammation and vascular integrity.Scientific reports · 2022Article
- Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres.Diagnostics (Basel, Switzerland) · 2021Review
- Diagnosis of Neuropathy and Risk Factors for Corneal Nerve Loss in Type 1 and Type 2 Diabetes: A Corneal Confocal Microscopy Study.Diabetes care · 2021Article
- Advances in Screening, Early Diagnosis and Accurate Staging of Diabetic Neuropathy.Frontiers in endocrinology · 2021Review
- Prevalence and Risk Factors for Diabetic Peripheral Neuropathy Among Saudi Hospitalized Diabetic Patients: A Nested Case-Control Study.International journal of general medicine · 2020Article
- Corneal confocal microscopy identifies greater corneal nerve damage in patients with a recurrent compared to first ischemic stroke.PloS one · 2020Article
- Diagnosing and managing diabetic somatic and autonomic neuropathy.Therapeutic advances in endocrinology and metabolism · 2019Review
- Explanations for less small fibre neuropathy in South Asian versus European subjects with type 2 diabetes in the UK.Diabetes/metabolism research and reviews · 2018Article
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10 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundLow foot ulcer risk in South Asian, compared with European, people with type 2 diabetes in the UK has been attributed to their lower levels of neuropathy. We have undertaken a detailed study of corneal nerve morphology and neuropathy risk factors, to establish the basis of preserved small nerve fibre function in South Asians versus Europeans.
methodsIn a cross-sectional, population-based study, age- and sex-matched South Asians (n = 77) and Europeans (n = 78) with type 2 diabetes underwent neuropathy assessment using corneal confocal microscopy, symptoms, signs, quantitative sensory testing, electrophysiology and autonomic function testing. Multivariable linear regression analyses determined factors accounting for ethnic differences in small fibre damage.
resultsCorneal nerve fibre length (22.0 ± 7.9 vs. 19.3 ± 6.3 mm/mm
conclusionsSouth Asians have better preserved small nerve fibre integrity than equivalent Europeans; furthermore, classic, modifiable risk factors for coronary heart disease are the main contributors to these ethnic differences. We suggest that improved autonomic neurogenic control of cutaneous blood flow in Asians may contribute to their protection against foot ulcers.
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