ArticleJournal of the American Geriatrics Society2018
Trajectories of Relative Performance with 2 Measures of Global Cognitive Function.
Article in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?GeroScience · 2023Article
- Investigating Predictors of Preserved Cognitive Function in Older Women Using Machine Learning: Women's Health Initiative Memory Study.Journal of Alzheimer's disease : JAD · 2021Article
- Distinct Cognitive Trajectories in Late Life and Associated Predictors and Outcomes: A Systematic Review.Journal of Alzheimer's disease reports · 2020Review
- Glycosylated hemoglobin level, race/ethnicity, and cognition in midlife and early old age.Research in human development · 2020Article
- Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease.Brain : a journal of neurology · 2020Article
- Article
- Design and baseline characteristics of the cocoa supplement and multivitamin outcomes study for the Mind: COSMOS-Mind.Contemporary clinical trials · 2019Article
- Using high-dimensional machine learning methods to estimate an anatomical risk factor for Alzheimer's disease across imaging databases.NeuroImage · 2018Article
- Multiracial participants in Alzheimer's research: scoping review and recommendations.Alzheimer's & dementia (New York, N. Y.)Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectivesTo examine whether trajectories of global cognitive function over time in studies that change assessment protocols may be modeled based on an individual's performance relative to others in the study cohort.
designExtended follow-up of a cohort originally enrolled in a clinical trial of postmenopausal hormone therapy.
settingThe Women's Health Initiative Memory Study switched from an in-person interview with the Modified Mini-Mental State Examination to a telephone-based interview with the modified Telephone Interview for Cognitive Status to assess global cognitive function over long-term follow-up.
participantsWomen aged 75 to 92 (N=2,561). MEASUREMENTS: Annual cognitive assessments from participants, ranked according to age-, race- and ethnicity-adjusted performance levels, were used to identify distinct trajectories. Participants assigned to the resulting trajectories were compared for selected risk factor profiles.
resultsOur approach grouped participants into five trajectories according to relative cognitive performance over time. These groups differed significantly according to 3 known risk factors for cognitive decline-education level, apolipoprotein E-ϵ4 genotype, and type 2 diabetes mellitus-and a biomarker based on brain structure that has been linked to cognitive decline and Alzheimer's disease. Participants with consistently low relative levels of cognitive function over time and those whose relative performance over time declined to these levels tended to have poorer risk factor profiles.
conclusionLongitudinal measures of an individual's relative performance on different assessment protocols for global cognitive function can be used to identify trajectories of change over time that appear to have internal validity with respect to known risk factors.
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