ArticleHuman brain mapping2018
Clinical subcategorization of minimally conscious state according to resting functional connectivity.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Advancing EEG-based assessment of consciousness and cognition in prolonged disorders of consciousness.Communications medicine · 2026Article
- PET in conjunction with resting-state functional MRI for the study of chronic disorders of consciousness.Brain communications · 2026Article
- Detecting rs-fMRI Networks in Disorders of Consciousness: Improving Clinical Interpretability.Annals of clinical and translational neurology · 2025Article
- Disorders of Consciousness, Language and Communication Following Severe Brain Injury.Psychologica Belgica · 2025Review
- Unveiling the axonal connectivity between the precuneus and temporal pole: Structural evidence from the cingulum pathways.Human brain mapping · 2024Article
- Minimally conscious state plus versus minus: Likelihood of emergence and long-term functional independence.Annals of clinical and translational neurology · 2024Article
- Behavioral scales variability in patients with prolonged disorders of consciousness.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Disorder of consciousness: Structural integrity of brain networks for the clinical assessment.Annals of clinical and translational neurology · 2023Article
- Resting-State fMRI in Chronic Patients with Disorders of Consciousness: The Role of Lower-Order Networks for Clinical Assessment.Brain sciences · 2022Article
- Prognostication, Ethical Issues, and Palliative Care in Disorders of Consciousness.Neurologic clinics · 2022Review
- Covert Cognition in Disorders of Consciousness: A Meta-Analysis.Brain sciences · 2020Article
- Joint Neuropsychological Assessment through Coma/Near Coma and Level of Cognitive Functioning Assessment Scales Reduces Negative Findings in Pediatric Disorders of Consciousness.Brain sciences · 2020Article
- Preservation of Language Processing and Auditory Performance in Patients With Disorders of Consciousness: A Multimodal Assessment.Frontiers in neurology · 2020Article
- Is the "Minimally Conscious State" Patient Minimally Self-Aware?Frontiers in psychology · 2020Review
- Auditory localization should be considered as a sign of minimally conscious state based on multimodal findings.Brain communications · 2020Article
- Post-comatose patients with minimal consciousness tend to preserve reading comprehension skills but neglect syntax and spelling.Scientific reports · 2019Article
- Reappearance of Command-Following Is Associated With the Recovery of Language and Internal-Awareness Networks: A Longitudinal Multiple-Case Report.Frontiers in systems neuroscience · 2019Article
- Clinical subcategorization of minimally conscious state according to resting functional connectivity.Human brain mapping · 2018Article
- Brain, Behavior, and Cognitive Interplay in Disorders of Consciousness: A Multiple Case Study.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients in minimally conscious state (MCS) have been subcategorized in MCS plus and MCS minus, based on command-following, intelligible verbalization or intentional communication. We here aimed to better characterize the functional neuroanatomy of MCS based on this clinical subcategorization by means of resting state functional magnetic resonance imaging (fMRI). Resting state fMRI was acquired in 292 MCS patients and a seed-based analysis was conducted on a convenience sample of 10 MCS plus patients, 9 MCS minus patients and 35 healthy subjects. We investigated the left and right frontoparietal networks (FPN), auditory network, default mode network (DMN), thalamocortical connectivity and DMN between-network anticorrelations. We also employed an analysis based on regions of interest (ROI) to examine interhemispheric connectivity and investigated intergroup differences in gray/white matter volume by means of voxel-based morphometry. We found a higher connectivity in MCS plus as compared to MCS minus in the left FPN, specifically between the left dorso-lateral prefrontal cortex and left temporo-occipital fusiform cortex. No differences between patient groups were observed in the auditory network, right FPN, DMN, thalamocortical and interhemispheric connectivity, between-network anticorrelations and gray/white matter volume. Our preliminary group-level results suggest that the clinical subcategorization of MCS may involve functional connectivity differences in a language-related executive control network. MCS plus and minus patients are seemingly not differentiated by networks associated to auditory processing, perception of surroundings and internal awareness/self-mentation, nor by interhemispheric integration and structural brain damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.