Evidence map›Paper›PMID 29972261›Full record

ArticleHuman brain mapping2018

Frequency-specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function.

Zhiyong Zhao, Chaozheng Tang, Dazhi Yin, Jie Wu, Jiayu Gong, Limin Sun, Jie Jia, Dongrong Xu, Mingxia Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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  20. Dynamic Structural and Functional Reorganizations Following Motor Stroke.Medical science monitor : international medical journal of experimental and clinical research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiyong ZhaoDepartment of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
Chaozheng TangDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Dazhi YinState Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Jie WuDepartment of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
Jiayu GongDepartment of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
Limin SunDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Jie JiaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Dongrong XuDepartment of psychiatry, New York State Psychiatric Institute and Columbia University, New York, New York.
Mingxia FanDepartment of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.ORCID 0000-0003-3303-7558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence has suggested that abnormalities in regional spontaneous brain activity following stroke may be detected by intrinsic low-frequency oscillations (LFO) in resting-state functional MRI (R-fMRI). However, the relationship between hand function outcomes following stroke and local LFO synchronization in different frequency bands is poorly understood. In this study, we performed R-fMRI to examine the regional homogeneity (ReHo) at three different frequency bands (slow-5: .01-.027 Hz; slow-4: .027-.08 Hz; and typical band: .01-.1 Hz) in 26 stroke patients with completely paralyzed hands (CPH) and 26 matched patients with partially paralyzed hands (PPH). Compared to the PPH group, decreased ReHo in the bilateral cerebellum posterior lobes and the contralesional cerebellum anterior lobe was observed in the slow-5 band and the slow-4 band in the CPH group, respectively. The mean ReHo values in these regions were positively correlated with the Fugl-Meyer assessment (FMA) scores. In contrast, increased ReHo in the contralesional supplementary motor area and the contralesional superior temporal gyrus was observed in the slow-4 band and the slow-5 band, respectively. The mean ReHo values in these regions were negatively correlated with the FMA scores. Importantly, significant interactions were identified between the frequency bands and the subgroups of patients in the contralesional precentral gyrus and middle frontal gyrus. These findings indicate that frequency-dependent R-fMRI patterns may serve as potential biomarkers of the neural substrates associated with hand function outcomes following stroke.

Indexed as

BrainBrain MappingFemaleHandHumansMagnetic Resonance ImagingMaleMiddle AgedParesisRestStrokecompletely paralyzed handsfrequency-dependentpartially paralyzed handsregional homogeneityresting-state fMRIstroke

Identifiers

PMID29972261
PMCPMC6866647

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.