ArticleJournal of neural engineering2018
Pallidal stimulation in Parkinson disease differentially modulates local and network β activity.
Article in Journal of neural engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease.Cell reports. Medicine · 2026Article
- Parkinson's disease severity is encoded by non-linear oscillatory interactions across cortical-subcortical networks.Scientific reports · 2026Article
- Parkinsonism disrupts the population-level organization of cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
- Predictors of motor outcome with pallidal stimulation for Parkinson's disease from the CSP468 cohort.NPJ Parkinson's disease · 2026Article
- Linking cortical morphology and neurophysiological dynamics in Parkinson's disease.Scientific reports · 2026Article
- A Canonical Neural Map and Its Deviations Shape Parkinson's Disease Phenotypes.Research square · 2026Article
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- Beta burst characteristics predict instantaneous hand movements in Parkinson's disease.Neurobiology of disease · 2025Article
- Linking Cortical Morphology and Neurophysiological Dynamics in Parkinson's Disease.Research square · 2025Article
- Alterations in beta oscillatory activity occur with the emergence of parkinsonian motor signs across the basal ganglia-thalamocortical network.Neurobiology of disease · 2025Article
- Multivariate Associations Between Neurophysiological Activity and Sensory Motor Cortical Morphometry in Parkinson's Disease.bioRxiv : the preprint server for biology · 2025Article
- B(RAIN)Scientific data · 2025Article
- Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson's disease.Brain : a journal of neurology · 2025Article
- Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation.NPJ Parkinson's disease · 2025Review
- Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Prefrontal-subthalamic theta signaling mediates delayed responses during conflict processing.Progress in neurobiology · 2024Article
- Automatic sleep-wake classification and Parkinson's disease recognition using multifeature fusion with support vector machine.CNS neuroscience & therapeutics · 2024Article
- Neural signatures of hyperdirect pathway activity in Parkinson's disease.Nature communications · 2021Article
- Movement-related changes in pallidocortical synchrony differentiate action execution and observation in humans.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
β hypersynchrony within the basal ganglia-thalamocortical (BGTC) network has been suggested as a hallmark of Parkinson disease (PD) pathophysiology. Subthalamic nucleus (STN)-DBS has been shown to alter cortical-subcortical synchronization. It is unclear whether this is a generalizable phenomenon of therapeutic stimulation across targets.
objectivesWe aimed to evaluate whether DBS of the globus pallidus internus (GPi) results in cortical-subcortical desynchronization, despite the lack of monosynaptic connections between GPi and sensorimotor cortex. APPROACH: We recorded local field potentials from the GPi and electrocorticographic signals from the ipsilateral sensorimotor cortex, off medications in nine PD patients, undergoing DBS implantation. We analyzed both local oscillatory power and functional connectivity (coherence and debiased weighted phase lag index (dWPLI)) with and without stimulation while subjects were resting with eyes open. MAIN
resultsDBS significantly suppressed low β power within the GPi (-26.98% ± 15.14%), p < 0.05) without modulation of sensorimotor cortical β power (low or high). In contrast, stimulation suppressed pallidocortical high β coherence (-38.89% ± 6.19%, p = 0.02) and dWPLI (-61.40% ± 8.75%, p = 0.02). Changes in cortical-subcortical functional connectivity were spatially specific to the motor cortex. SIGNIFICANCE: We highlight the role of DBS in desynchronizing network activity, particularly in the high β band. The current study of GPi-DBS suggests these network-level effects are not necessarily dependent and potentially may be independent of the hyperdirect pathway. Importantly, these results draw a sharp distinction between the potential significance of low β oscillations locally within the basal ganglia and high β oscillations across the BGTC motor circuit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.