ArticleJournal of clinical neurology (Seoul, Korea)2018
Effect of Vitamin D Deficiency on the Frequency of Headaches in Migraine.
Article in Journal of clinical neurology (Seoul, Korea), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Comorbidities of primary headache disorders: a literature review with meta-analysis.The journal of headache and pain · 2021Pooled it
- Vitamin D in migraine headache: a comprehensive review on literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- From the Perspective of the Peripheral Sensory Nervous System: The Role of Vitamin D in Neurogenic Inflammatory Skin Disorders.Acta physiologica (Oxford, England) · 2026Review
- Vitamin D Deficiency and Supplementation in Migraine: A Scoping Review of Clinical Efficacy, Evidence Gaps, and Research Priorities.Annals of Indian Academy of Neurology · 2026Article
- Vitamin D and Brain Health.Advances in experimental medicine and biology · 2026Review
- Article
- Pediatric Headache Patients Are at High Risk of Vitamin D Insufficiency.Journal of child neurology · 2025Article
- Vitamin D and Neurological Health: Unraveling Risk Factors, Disease Progression, and Treatment Potential.CNS & neurological disorders drug targets · 2025Review
- The TRPA1 Ion Channel Mediates Oxidative Stress-Related Migraine Pathogenesis.Molecules (Basel, Switzerland) · 2024Review
- Benefit of Dietary Supplementation of Nutraceuticals as an Integrative Approach for Management of Migraine: Evidence From Preclinical and Clinical Studies.Current pain and headache reports · 2024Review
- Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database.Food & nutrition research · 2024Article
- Review
- Vitamin D receptor and binding protein genes variants in patients with migraine.Annals of clinical and translational neurology · 2023Article
- Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine.Nutrients · 2023Review
- Genetic Variability in Vitamin D Receptor and Migraine Susceptibility: A Southeastern European Case-Control Study.Neurology international · 2023Article
- Serum vitamin D le Serum vitamin D levels are associated with acute post e associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystect cholecystectomy: a str omy: a strobe compliant pr obe compliant prospectiv ospective obser e observational ational study.Turkish journal of medical sciences · 2023Observational
- Vitamin D in Neurological Diseases.International journal of molecular sciences · 2022Review
- Elevated Bone Resorption Markers in Patients With Migraine: A Case Series.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Review on Headache Related to Dietary Supplements.Current pain and headache reports · 2022Review
- Higher Circulating Vitamin D Levels Are Associated With Decreased Migraine Risk: A Mendelian Randomization Study.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe risk of vitamin D deficiency varies with the season. The frequency of vitamin D deficiency in migraine patients and its association with migraine are unclear.
methodsWe retrospectively evaluated first-visit migraine patients between January 2016 and May 2017, and investigated the demographics, season, migraine subtypes, frequency, severity, and impact of migraine, psychological and sleep variables, climate factors, and vitamin D levels. The nonfasting serum 25-hydroxyvitamin D concentration was measured to determine the vitamin D level, with deficiency of vitamin D defined as a concentration of <20 ng/mL.
resultsIn total, 157 patients with migraine aged 37.0±8.6 years (mean±standard deviation) were analyzed. Their serum level of vitamin D was 15.9±7.4 ng/mL. Vitamin D deficiency was present in 77.1% of the patients, and occurred more frequently in spring and winter than in summer and autumn (89.1%, 85.7%, 72.4%, and 61.7%, respectively; p=0.008). In multivariate Poisson regression analysis, monthly headache was 1.203 times (95% confidence interval=1.046-1.383, p=0.009) more frequent in patients with vitamin D deficiency than in those without deficiency after adjusting for demographics, season, migraine subtype, depression, anxiety, and sleep quality. These associations were consistently noted in subgroup analysis of episodic migraine (odds ratio=1.266, p=0.033) and chronic migraine (odds ratio=1.390, p=0.041).
conclusionsOur study found that a larger number of monthly days with headache was related to vitamin D deficiency among migraineurs. Future studies should attempt to confirm the causal relationship between vitamin D deficiency and migraine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.