ArticleAngewandte Chemie (International ed. in English)2018
Selection of Secondary Structures of Heterotypic Supramolecular Peptide Assemblies by an Enzymatic Reaction.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Sequence-Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides.ChemistryEurope · 2026Article
- Super-Resolution Microscopy as a Versatile Tool in Probing Molecular Assembly.International journal of molecular sciences · 2024Review
- Article
- Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics.Nanomaterials (Basel, Switzerland) · 2023Review
- An Exploration of Multiple Component Peptide Assemblies by Enzyme-Instructed Self-Assembly.ChemSystemsChem · 2023Article
- Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides.Soft matter · 2021Article
- Heterotypic Supramolecular Hydrogels Formed by Noncovalent Interactions in Inflammasomes.Molecules (Basel, Switzerland) · 2020Article
- Sequence-Dependent Nanofiber Structures of Phenylalanine and Isoleucine Tripeptides.International journal of molecular sciences · 2020Article
- Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials.ACS nano · 2020Article
- Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo.Nature nanotechnology · 2020Article
- Enzymatic Noncovalent Synthesis of Supramolecular Soft Matter for Biomedical Applications.Matter · 2019Article
- Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma.Acta pharmaceutica Sinica. B · 2019Article
- Assemblies of Peptides in a Complex Environment and their Applications.Angewandte Chemie (International ed. in English) · 2019Review
- Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly.ACS nano · 2019Article
- Stoichiometry-controlled secondary structure transition of amyloid-derived supramolecular dipeptide co-assemblies.Communications chemistry · 2019Article
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6 authors.
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Abstract
In a model study to investigate the consequence of reactions of intrinsically disordered regions (IDRs) of proteins in the context of the formation of highly ordered structures, we found that enzymatic reactions control the secondary structures of peptides during assembly. Specifically, phosphorylation of an α-helix-dominant peptide results in mostly disordered conformations, which become β-strand-dominant after enzymatic dephosphorylation to regenerate the peptide. In the presence of another peptide largely with a β-strand conformation, direct coassembly of the peptides results in amorphous aggregates consisting of α-helix and β-strand peptides, but the enzymatically generated peptide coassemblies (from the phosphopeptide) mainly adopt a β-strand conformation and form ordered structures (e.g., nanofibers). These results indicate that enzymatic dephosphorylation instructs conformationally flexible peptides to adopt thermodynamically favorable conformations in homotypic or heterotypic supramolecular assemblies.
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