ArticleBiological reviews of the Cambridge Philosophical Society2019
The evolutionary origins of pesticide resistance.
Article in Biological reviews of the Cambridge Philosophical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers, 2 of them syntheses that pooled it.
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Who cites it
234 citing papers in PubMed, 2 syntheses or guidelines pooled it, 796 citations in OpenAlex.
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- From Rhizosphere to Resistance: Microbe-Plant Interactions in Eco-Smart Biocontrol.MicrobiologyOpen · 2026Review
- Assessing the potential for insecticide cross-resistance to a novel insecticide in the Colorado potato beetle (Leptinotarsa decemlineata) using phenotypic and transcript expression analysis.Pest management science · 2026Article
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- Genomic analysis of population structure and target-site mutations of Tetranychus truncatus in China.Pest management science · 2026Article
- Divergent mechanisms of active antibiotic resistance gene enrichment in soil driven by pesticide diversity.Nature communications · 2026Article
- Investigating zeta-cypermethrin resistance stability in California Drosophila suzukii populations.Pest management science · 2026Article
- Partially occluded weed classification using vision transformers and convolutional neural networks for precision agriculture.Scientific reports · 2026Article
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- RNAi targeting ABCB1-like efflux transporters improves miticide efficacy in resistant Varroa mites.Parasites & vectors · 2026Article
- Susceptibility of Phthorimaea absoluta (Meyrick) (Lepidoptera: Gelechiidae) to novel and established insecticides in Brazil: resistance survey, baseline, and implications for management.Pest management science · 2026Article
- Physiological and Biochemical Responses of Two Major Legume Crops to Seed Priming-A Systematic Review.Plants (Basel, Switzerland) · 2026Review
174 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Durable crop protection is an essential component of current and future food security. However, the effectiveness of pesticides is threatened by the evolution of resistant pathogens, weeds and insect pests. Pesticides are mostly novel synthetic compounds, and yet target species are often able to evolve resistance soon after a new compound is introduced. Therefore, pesticide resistance provides an interesting case of rapid evolution under strong selective pressures, which can be used to address fundamental questions concerning the evolutionary origins of adaptations to novel conditions. We ask: (i) whether this adaptive potential originates mainly from de novo mutations or from standing variation; (ii) which pre-existing traits could form the basis of resistance adaptations; and (iii) whether recurrence of resistance mechanisms among species results from interbreeding and horizontal gene transfer or from independent parallel evolution. We compare and contrast the three major pesticide groups: insecticides, herbicides and fungicides. Whilst resistance to these three agrochemical classes is to some extent united by the common evolutionary forces at play, there are also important differences. Fungicide resistance appears to evolve, in most cases, by de novo point mutations in the target-site encoding genes; herbicide resistance often evolves through selection of polygenic metabolic resistance from standing variation; and insecticide resistance evolves through a combination of standing variation and de novo mutations in the target site or major metabolic resistance genes. This has practical implications for resistance risk assessment and management, and lessons learnt from pesticide resistance should be applied in the deployment of novel, non-chemical pest-control methods.
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