Evidence map›Paper›PMID 29971803›Full record

ArticleThe New phytologist2018

Cytosolic malate and oxaloacetate activate S-type anion channels in Arabidopsis guard cells.

Cun Wang, Jingbo Zhang, Juyou Wu, Dennis E Brodsky, Julian I Schroeder

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New phytologist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Signaling mechanisms in abscisic acid-mediated stomatal closure.The Plant journal : for cell and molecular biology · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Cun WangCell and Developmental Biology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, 92093-0116, USA.
Jingbo ZhangCell and Developmental Biology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, 92093-0116, USA.
Juyou WuCell and Developmental Biology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, 92093-0116, USA.
Dennis E BrodskyCell and Developmental Biology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, 92093-0116, USA.
Julian I SchroederCell and Developmental Biology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, 92093-0116, USA.
University of California, San Diego · USNorthwest A&F University · CN

Funding

STRESS HORMONE SIGNAL TRANSDUCTION IN ARABIDOPSISR01GM060396 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHROEDER, JULIAN I · 2000 to 2023
$7.4M
NIGMS NIH HHS R01 GM060396
6 · The paper itself

Abstract

Intracellular malate-starch interconversion plays an important role in stomatal movements. We investigated whether malate or oxaloacetate from the cytosolic membrane side regulate anion channels in the plasma membrane of Arabidopsis thaliana guard cells. Physiological concentrations of cytosolic malate have been reported in the range of 0.4-3 mM in leaf cells. Guard cell patch clamp and two-electrode oocyte voltage-clamp experiments were pursued. We show that a concentration of 1 mM cytosolic malate greatly activates S-type anion channels in Arabidopsis thaliana guard cells. Interestingly, 1 mM cytosolic oxaloacetate also activates S-type anion channels. Malate activation was abrogated at 10 mM malate and in SLAC1 anion channel mutant alleles. Interestingly, malate activation of S-type anion currents was disrupted at below resting cytosolic-free calcium concentrations ([Ca

Indexed as

Ion Channel GatingAnimalsArabidopsisCytosolIon ChannelsMalatesMutationOxaloacetic AcidPlant StomataXenopus laevisIon ChannelsMalatesOxaloacetic AcidArabidopsisCl− channelion channel regulationmalic acidstomata

Identifiers

PMID29971803
PMCPMC6115288
OpenAlexW2810592212

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.