Evidence map›Paper›PMID 29971575›Full record

ReviewCurrent cardiology reports2018

Cardiovascular Autonomic Dysfunction in Patients with Cancer.

Ben G T Coumbe, John D Groarke

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05081115 (The International Stress Echo Study to to Define the Future of Imaging), which is not on this map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05081115 recruitingnot on this mapstarted 2021, after this paper: background citation

The International Stress Echo Study to to Define the Future of Imaging

Typeobservational_patient_registrySponsorFatebenefratelli HospitalRan2021 to 2030Enrolled10,000ConditionsCoronary Artery Disease, Heart Failure, Hypertrophic Cardiomyopathy, Congenital Heart DiseaseArmsABCDE-Stress Echo, SE diastolic assessment, SE Right ventricular function assessment, SE in heart donors
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  8. Symptom burden and symptom clusters in ovarian cancer patients during first-line maintenance therapy: a cross-sectional survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  17. Exercise Prescription in Cardio-Oncology.Journal of clinical medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Ben G T CoumbeSchool of Clinical Medicine, University College London Medical School, Gower Street, London, WC1E 6BT, UK.
John D GroarkeDivision of Cardiovascular Medicine, Brigham and Women's Hospital Heart and Vascular Center/Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. jgroarke@bwh.harvard.edu.
Brigham and Women's Hospital · USUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewElucidating the mechanisms that contribute to adverse cardiovascular (CV) outcomes and reduce quality of life among patients with cancer is paramount. Cancer, certain cancer drugs, radiation therapy, cancer-associated lifestyle disturbances, and cancer-independent comorbidities combine to predispose oncology patients to autonomic dysfunction (AD). This review will explore the assessment, etiology, and clinical implications of AD in cancer patients and will speculate on therapeutic and research opportunities. RECENT

findingsAD is particularly prevalent among patients with advanced cancer, but studies suggest increased prevalence across the entire continuum of cancer survivors compared to cancer-free controls. Data on cancer therapy-induced injury to the autonomic nervous system are limited to small studies. AD has been reported after cranial, neck, and mediastinal radiation therapy. Although AD has been shown to confer increased risk of adverse CV outcomes in cancer-free patients, the prognostic relevance of AD in oncology patients is less well investigated. Markers of AD including elevated resting heart rate (HR), reduced HR variability, and abnormal HR recovery have been associated with shorter survival times in various cancer cohorts. Furthermore, AD has been implicated in the etiology of cancer-related fatigue and exercise limitation. Multiple risk factors predispose oncology patients to AD, which is associated with adverse outcomes, including increased mortality, exercise limitation, and fatigue among this cohort. The contribution of AD to overall morbidity and mortality in cancer survivors has largely been overlooked to date. Further investigation is necessary to better understand cancer-treatment specific autonomic injury and to evaluate the role of various pharmacological and non-pharmacological interventions with potential to tackle the sympathovagal imbalance observed in cancer survivors.

Indexed as

Cancer SurvivorsAutonomic Nervous SystemAutonomic Nervous System DiseasesCardiovascular SystemDrug-Related Side Effects and Adverse ReactionsHeart RateHumansNeoplasmsQuality of LifeRadiotherapyRisk FactorsAutonomic dysfunctionCardio-oncologyCardiotoxicityChemotherapyHeart rate variabilityRadiation therapy

Identifiers

PMID29971575
OpenAlexW2810014814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.