ArticleEJNMMI research2018
Non-invasive kinetic modelling of PET tracers with radiometabolites using a constrained simultaneous estimation method: evaluation with
Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies.European journal of nuclear medicine and molecular imaging · 2023Pooled it
- "Pseudo-reference-based Input Function Shape" (pRef-IFS): Towards a True image-derived input function for PET kinetic modeling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Total-body positron emission tomography imaging to accelerate radiotracer discovery pipelines.Pharmacological reviews · 2025Review
- Evaluating image-derived input functions for cerebral [Frontiers in nuclear medicine · 2025Article
- Optimization-derived blood input function using a kernel method and its evaluation with total-body PET for brain parametric imaging.NeuroImage · 2024Article
- Non-invasive quantification ofEJNMMI research · 2024Article
- Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [EJNMMI physics · 2024Article
- A shortEJNMMI research · 2024Article
- Non-invasive quantification ofResearch square · 2023Article
- Quantitation of dynamic total-body PET imaging: recent developments and future perspectives.European journal of nuclear medicine and molecular imaging · 2023Review
- Development of a minimally invasive simultaneous estimation method for quantifying translocator protein binding with [EJNMMI research · 2023Article
- Challenges and innovations in brain PET analysis of neurodegenerative disorders: a mini-review on partial volume effects, small brain region studies, and reference region selection.Frontiers in neuroscience · 2023Review
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundKinetic analysis of dynamic PET data requires an accurate knowledge of available PET tracer concentration within blood plasma over time, known as the arterial input function (AIF). The gold standard method used to measure the AIF requires serial arterial blood sampling over the course of the PET scan, which is an invasive procedure and makes this method less practical in clinical settings. Traditional image-derived methods are limited to specific tracers and are not accurate if metabolites are present in the plasma.
resultsIn this work, we utilise an image-derived whole blood curve measurement to reduce the computational complexity of the simultaneous estimation method (SIME), which is capable of estimating the AIF directly from tissue time activity curves (TACs). This method was applied to data obtained from a serotonin receptor study (
conclusionsThe results of this work indicate that the proposed method with prior AIF information obtained from a partial volume corrected image-derived whole blood curve, and modelled parent fraction, has the potential to be used as an alternative non-invasive method to perform kinetic analysis of tracers with metabolite products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.