ArticleJournal of materials science. Materials in medicine2018
Biomechanical and morphological stability of acellular scaffolds for tissue-engineered heart valves depends on different storage conditions.
Article in Journal of materials science. Materials in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Mechanical and Structural Adaptation of the Pulmonary Root after Ross Operation in a Murine Model.Journal of clinical medicine · 2022Article
- The useful agent to have an ideal biological scaffold.Cell and tissue banking · 2021Review
- Recent Advances in Scaffolding from Natural-Based Polymers for Volumetric Muscle Injury.Molecules (Basel, Switzerland) · 2021Review
- Development and Characterization of a Benchtop Corneal Puncture Injury Model.Scientific reports · 2020Article
- Status of Plant Protein-Based Green Scaffolds for Regenerative Medicine Applications.Biomolecules · 2019Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Currently available bioprosthetic heart valves have been successfully used clinically; however, they have several limitations. Alternatively, tissue-engineering techniques can be used. However, there are limited data concerning the impact of storage conditions of scaffolds on their biomechanics and morphology. The aim of this study was to determine the effect of different storage conditions on the biomechanics and morphology of pulmonary valve dedicated for the acellular scaffold preparation to achieve optimal conditions to obtain stable heart valve prostheses. Scaffold can then be used for the construction of tissue-engineered heart valve, for this reason evaluation of these parameters can determine the success of the clinical application this type of bioprosthesis. Pulmonary heart valves were collected from adult porcines. Materials were divided into five groups depending on the storage conditions. Biomechanical tests were performed, both the static tensile test, and examination of viscoelastic properties. Extracellular matrix morphology was evaluated using transmission electron microscopy and immunohistochemistry. Tissue stored at 4 °C exhibited a higher modulus of elasticity than the control (native) and fresh acellular, which indicated the stiffening of the tissue and changes of the viscoelastic properties. Such changes were not observed in the radial direction. Percent strain was not significantly different in the study groups. The storage conditions affected the acellularization efficiency and tissue morphology. To the best of our knowledge, this study is the first that attributes the mechanical properties of pulmonary valve tissue to the biomechanical changes in the collagen network due to different storage conditions. Storage conditions of scaffolds for tissue-engineered heart valves may have a significant impact on the haemodynamic and clinical effects of the used bioprostheses.
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