ReviewWorld journal of microbiology & biotechnology2018
The role of dissolved oxygen content as a modulator of microbial polyhydroxyalkanoate synthesis.
Review in World journal of microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Microaerobic dark fermentation by purple bacteria as an emerging perspective for biohydrogen production-a review.Biotechnology for biofuels and bioproducts · 2026Review
- SBR operational strategies for directing mixed microbial cultures toward levulinic acid production using hexoses.Frontiers in bioengineering and biotechnology · 2026Article
- Polyhydroxyalkanoate (PHA) production by landfill isolate Priestia sp. revealed by preparatory glucose-induced tests and genome-annotations.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Production and characterization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymers from a pre- fermented hardwood hydrolysate.Bioprocess and biosystems engineering · 2025Article
- Tailoring 3HV Fraction in Poly(3-hydroxybutyrate-Polymers · 2025Article
- A review on microbes mediated resource recovery and bioplastic (polyhydroxyalkanoates) production from wastewater.Microbial cell factories · 2024Review
- PHB production by Bacillus megaterium strain MNSH1-9K-1 using low-cost media.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Effect of oxic and anoxic conditions on intracellular storage of polyhydroxyalkanoate and polyphosphate inFrontiers in microbiology · 2023Article
- Biogeochemical properties of blue carbon sediments influence the distribution and monomer composition of bacterial polyhydroxyalkanoates (PHA).Biogeochemistry · 2023Article
- Article
- Extended batch cultures for poly(3-hydroxybutyrate-3 Biotech · 2022Article
- High Cell Density Cultivation ofFrontiers in bioengineering and biotechnology · 2022Article
- The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles.Polymers · 2021Review
- Enhanced production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) biopolymer by recombinant Bacillus megaterium in fed-batch bioreactors.Bioprocess and biosystems engineering · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Polyhydroxyalkanoates (PHAs) are a diverse class of bio-polymers synthesized by bacteria, usually during imbalanced growth conditions. Optimizing PHA productivity is highly dependent on the bioreactor oxygen transfer rate (OTR), which is an important consideration for process performance and economics, particularly with increasing scale. Relatively few in-depth studies are available regarding the effect of OTR and dissolved oxygen content (DOC) on PHA formation, synthesis rates, composition, and characteristics. This review examines past research studies on the effect of low DOC environments on production of short-chain length (scl-) PHAs, synthesized by both pure and mixed cultures, in order to identify opportunities and gaps concerning the effect of DOC on production of medium-chain length (mcl-) PHAs, an area that has not been studied in detail. The literature indicates that production of scl-PHA (a reductive process) acts as an electron sink allowing cells to maintain balanced redox state at low DOC. Conversely, production of mcl-PHA via fatty acid de novo synthesis (also a reductive process) does not occur to any significant extent in low DOC environments, while mcl-PHA synthesis from fatty acids (an oxidative process) can be promoted in low DOC environments. The monomer composition, molecular mass, as well as physical and thermal properties of the polymer can change in response to OTR, but further research in this area is required for both scl- and mcl-PHAs. Process design and management of bioreactor OTR in PHA production might therefore be directed by the final application of the polymer rather than cost considerations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.