Evidence map›Paper›PMID 29971320›Full record

ArticleJAMA internal medicine2018

The Carbohydrate-Insulin Model of Obesity Is Difficult to Reconcile With Current Evidence.

Kevin D Hall, Stephan J Guyenet, Rudolph L Leibel

Abstract readComment
PubMed Publisher
In one paragraph

Article in JAMA internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The association between adverse childhood experiences and childhood obesity: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Pooled it
  2. Pooled it
  3. Trial
  4. Triglyceride Accumulation in Adipocytes Modulated by Insulin Dynamics.International journal of molecular sciences · 2025
    Article
  5. International society of sports nutrition position stand: ketogenic diets.Journal of the International Society of Sports Nutrition · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Diet composition and energy intake in humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  11. Carbohydrate-insulin model: does the conventional view of obesity reverse cause and effect?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Caloric RestrictionNutrients · 2021
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Kevin D HallNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Stephan J Guyenet
Rudolph L LeibelColumbia University, New York, New York.

Funding

Modeling interactions of diet, exercise, metabolism, and weight change in humansZIADK013037 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI DARCEY, VALERIE · 2009 to 2025
$10.8M
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

InsulinObesityCarbohydratesEnergy IntakeHumansCarbohydratesInsulin

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.