Evidence map›Paper›PMID 29971151›Full record

ArticleBJPsych open2018

Mental health in UK Biobank: development, implementation and results from an online questionnaire completed by 157 366 participants.

Katrina A S Davis, Jonathan R I Coleman, Mark Adams, Naomi Allen, Gerome Breen, Breda Cullen, Chris Dickens, Elaine Fox, Nick Graham, Jo Holliday and 11 more

RetractedErratum issuedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BJPsych open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 53 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Katrina A S DavisInstitute of Psychiatry Psychology and Neuroscience, King's College London, South London and Maudsley NHS Foundation Trust and NIHR Biomedical Research Centre, London, UK.ORCID 0000-0001-5945-4646
Jonathan R I ColemanInstitute of Psychiatry Psychology and Neuroscience, King's College London, South London and Maudsley NHS Foundation Trust and NIHR Biomedical Research Centre, London, UK.
Mark AdamsDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Naomi AllenUK Biobank and Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Oxford, UK.
Gerome BreenInstitute of Psychiatry Psychology and Neuroscience, King's College London, South London and Maudsley NHS Foundation Trust and NIHR Biomedical Research Centre, London, UK.
Breda CullenMental Health and Wellbeing, University of Glasgow, and The Academic Centre, Gartnavel Royal Hospital, Glasgow, UK.
Chris DickensInstitute of Health Research, University of Exeter Medical School, Exeter, UK.
Elaine FoxDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
Nick GrahamInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Jo HollidayUK Biobank and Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Oxford, UK.
Louise M HowardInstitute of Psychiatry Psychology and Neuroscience: Section of Women's Mental Health, King's College London and David Goldberg Centre, London, UK.
Ann JohnFarr Institute of Health Informatics Research, Swansea University Medical School, Swansea, UK.
William LeePlymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, and Devon Partnership NHS Trust, Exeter, UK.
Rose McCabeUniversity of Exeter Medical School, Exeter, UK.
Andrew McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Robert PearsallInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Daniel J SmithInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Cathie SudlowUK Biobank and Centre for Medical Informatics, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Joey WardInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Stan ZammitCentre for Academic Mental Health, University of Bristol, Bristol, and Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.
Matthew HotopfInstitute of Psychiatry Psychology and Neuroscience, King's College London, South London and Maudsley NHS Foundation Trust, and NIHR Biomedical Research Centre, London, UK.

Funding

Department of Health NIHR-RP-R3-12-011Department of Health PB-PG-0408-16279Department of Health PB-PG-1111-26063Medical Research Council G0401323Medical Research Council MC_PC_17209Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/K026992/1Medical Research Council MR/L010305/1
6 · The paper itself

Abstract

backgroundUK Biobank is a well-characterised cohort of over 500 000 participants that offers unique opportunities to investigate multiple diseases and risk factors.

aimsAn online mental health questionnaire completed by UK Biobank participants was expected to expand the potential for research into mental disorders.

methodAn expert working group designed the questionnaire, using established measures where possible, and consulting with a patient group regarding acceptability. Case definitions were defined using operational criteria for lifetime depression, mania, anxiety disorder, psychotic-like experiences and self-harm, as well as current post-traumatic stress and alcohol use disorders.

results157 366 completed online questionnaires were available by August 2017. Comparison of self-reported diagnosed mental disorder with a contemporary study shows a similar prevalence, despite respondents being of higher average socioeconomic status than the general population across a range of indicators. Thirty-five per cent (55 750) of participants had at least one defined syndrome, of which lifetime depression was the most common at 24% (37 434). There was extensive comorbidity among the syndromes. Mental disorders were associated with high neuroticism score, adverse life events and long-term illness; addiction and bipolar affective disorder in particular were associated with measures of deprivation.

conclusionsThe questionnaire represents a very large mental health survey in itself, and the results presented here show high face validity, although caution is needed owing to selection bias. Built into UK Biobank, these data intersect with other health data to offer unparalleled potential for crosscutting biomedical research involving mental health. DECLARATION OF INTEREST: G.B. received grants from the National Institute for Health Research during the study; and support from Illumina Ltd. and the European Commission outside the submitted work. B.C. received grants from the Scottish Executive Chief Scientist Office and from The Dr Mortimer and Theresa Sackler Foundation during the study. C.S. received grants from the Medical Research Council and Wellcome Trust during the study, and is the Chief Scientist for UK Biobank. M.H. received grants from the Innovative Medicines Initiative via the RADAR-CNS programme and personal fees as an expert witness outside the submitted work.

Identifiers

PMID29971151
PMCPMC6020276

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.