Evidence map›Paper›PMID 29971149›Full record

ArticleBJPsych open2018

The prevalence and treatment outcomes of antineuronal antibody-positive patients admitted with first episode of psychosis.

James G Scott, David Gillis, Alex E Ryan, Hethal Hargovan, Nagaraj Gundarpi, Gemma McKeon, Sean Hatherill, Martin P Newman, Peter Parry, Kerri Prain and 4 more

Open access · goldAbstract read
In one paragraph

Article in BJPsych open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Neural Antibodies in First-episode Psychosis Patients with Warning Signs for Autoimmune Encephalitis.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024
    Article
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  14. Article
  15. Article
  16. BJPsych open · 2020
    Article
  17. Testing forThe Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2020
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

James G ScottCentre for Clinical Research, The University of Queensland (UQCCR), Metro North Mental Health, Royal Brisbane and Women's Hospital (RBWH), and the Queensland Centre for Mental Health Research (QCMHR), Australia.
David GillisDivision of Immunology, Pathology Queensland Central Laboratory, RBWH, Australia.
Alex E RyanUQCCR and QCMHR, Australia.
Hethal HargovanMetro North Mental Health, RBWH, Australia.
Nagaraj GundarpiMetro North Mental Health, RBWH, Australia.
Gemma McKeonMAPS, UQCCR and QCMHR, Australia.
Sean HatherillMetro South Addiction and Mental Health Service, Child and Youth Academic Clinical Unit, Queensland, Australia.
Martin P NewmanDivision of Immunology, Pathology Queensland Central Laboratory, RBWH, and Faculty of Medicine, University of Queensland, Australia.
Peter ParryChild and Youth Mental Health Service, Children's Health Queensland, Australia.
Kerri PrainDivision of Immunology, Pathology Queensland Central Laboratory, RBWH, Australia.
Sue PattersonMetro North Mental Health, RBWH, and Department of Applied Psychology, Griffith University, Queensland, Australia.
Richard C W WongDivision of Immunology, Pathology Queensland Central Laboratory, RBWH, and Department of Immunology, Princess Alexandra Hospital, Queensland, Australia.
Robert J WilsonDivision of Immunology, Pathology Queensland Central Laboratory, RBWH, and Department of Immunology, Princess Alexandra Hospital, Queensland, Australia.
Stefan BlumFaculty of Medicine, University of Queensland and Department of Neurology, Princess Alexandra Hospital, Queensland, Australia.
Queensland Centre for Mental Health Research · AUPrincess Alexandra Hospital · AUThe University of Queensland · AUChildren’s Health Queensland Hospital and Health Service · AUGriffith University · AUMetro South Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntineuronal antibodies are associated with psychosis, although their clinical significance in first episode of psychosis (FEP) is undetermined.

aimsTo examine all patients admitted for treatment of FEP for antineuronal antibodies and describe clinical presentations and treatment outcomes in those who were antibody positive.

methodIndividuals admitted for FEP to six mental health units in Queensland, Australia, were prospectively tested for serum antineuronal antibodies. Antibody-positive patients were referred for neurological and immunological assessment and therapy.

resultsOf 113 consenting participants, six had antineuronal antibodies (anti-

conclusionsA small subgroup of patients admitted to hospital with FEP have antineuronal antibodies detectable in serum and are responsive to immunotherapy. Early diagnosis and treatment is critical to optimise recovery. DECLARATION OF INTEREST: None.

Identifiers

PMID29971149
PMCPMC6020277
OpenAlexW2789656770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.