ArticleJournal of dentistry (Tehran, Iran)2018
Minimum Intracanal Dressing Time of Triple Antibiotic Paste to Eliminate Enterococcus Faecalis (ATCC 29212) and Determination of Minimum Inhibitory Concentration and Minimum Bactericidal Concentration: An Ex Vivo Study.
Article in Journal of dentistry (Tehran, Iran), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- Antibacterial efficacy of calcium hydroxide, polyantibiotic paste, andJournal of conservative dentistry and endodontics · 2026Article
- Novel approaches on root canal disinfection methods againstJournal of oral microbiology · 2025Review
- Article
- Targeting Persistent Biofilm Infections: Reconsidering the Topography of the Infection Site during Model Selection.Microorganisms · 2022Review
- Antibacterial Activity of Various Intracanal Medicament againstJournal of pharmacy & bioallied sciences · 2021Article
- Characterization of Enterococcus faecalis in different culture conditions.Scientific reports · 2020Article
- Assessment of Nitrofurantoin as an Experimental Intracanal Medicament in Endodontics.BioMed research international · 2020Article
- Comparison of Antimicrobial Effects of Triple Antibiotic Paste and Calcium Hydroxide Mixed with 2% Chlorhexidine as Intracanal Medicaments Against Enterococcus faecalis Biofilm.Journal of dentistry (Tehran, Iran) · 2018Article
- Effect of triple antibiotic paste and calcium hydroxide on the rate of healing of periapical lesions: A systematic review.Journal of conservative dentistry : JCDReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEnterococcus faecalis (E. faecalis) is the most commonly isolated microorganism from teeth with postoperative infection. Triple antibiotic paste (TAP) has the ability to eradicate microorganisms from the root canal system when used as an intracanal medicament. The aim of this study was to determine the minimum duration of application of TAP required for elimination of E. faecalis from the root canal system and its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) in an ex-vivo model. MATERIALS AND
methodsRoot canals of 34 extracted human single canal teeth were inoculated with E. Faecalis after instrumentation, and then 4 g of TAP (ciprofloxacin, metronidazole and doxycycline) was mixed with 4.5 mL of saline and applied as intracanal medicament. The teeth were sectioned longitudinally and dentin chips were collected and evaluated to determine the count of bacterial colonies. Micro-dilution broth test was used to assess the MIC and MBC of TAP. Data were analyzed using SPSS version 22 via the Wilcoxon signed rank test.
resultsAfter seven days of application of TAP as intracanal medicament, E. faecalis was eliminated from the dentinal tubules of the apical half of root canal up to 400 μ depth. The MIC and MBC of TAP in its original concentration were both found to be 16 μg/mL.
conclusionsThe original concentration of TAP was found to be 5×10
Indexed as
Identifiers
29971116PMC6026102What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.