ArticleInternational journal of endocrinology2018
Diagnostic Values of Free Triiodothyronine and Free Thyroxine and the Ratio of Free Triiodothyronine to Free Thyroxine in Thyrotoxicosis.
Article in International journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- The Free T3/Free T4 Ratio Predicts Relapse After Antithyroid Drug Withdrawal in Pediatric Autoimmune Hyperthyroidism.The Journal of clinical endocrinology and metabolism · 2026Article
- Variations in Circulating Thyroid Hormone Profiles Across Age, Sex, and Pregnancy Outcomes in Killer Whales (Animals : an open access journal from MDPI · 2026Article
- Behavior of serum thyroglobulin in relation to thyroid function under low-thyrotropin conditions in general practice.Frontiers in endocrinology · 2026Article
- Utility of the FT3-to-FT4 ratio as a screening marker for pediatric Graves' disease.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2025Article
- Establishment of Reference Intervals for Serum Thyroid-related Hormones in the Chinese Oldest-old.International journal of medical sciences · 2025Article
- Association between sensitivity to thyroid hormone and prognosis in septic patients: a retrospective cohort analysis.Frontiers in endocrinology · 2025Article
- Impaired sensitivity to thyroid hormones is associated with high lipoprotein(a) level in euthyroid patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- The Free Thyroxine-to-Thyroid Stimulating Hormone Ratio: A Potential Diagnostic Marker for Graves' Disease.International journal of endocrinology and metabolism · 2025Article
- Article
- Assessment of the association between genetic factors regulating thyroid function and microvascular complications in diabetes: A two-sample Mendelian randomization study in the European population.Frontiers in endocrinology · 2023Article
- The value of FT4/TSH ratio in the differential diagnosis of Graves' disease and subacute thyroiditis.Frontiers in endocrinology · 2023Article
- Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort.Frontiers in endocrinology · 2023Article
- Subacute Thyroiditis-Still a Diagnostic Challenge: Data from an Observational Study.International journal of environmental research and public health · 2022Observational
- Indirect estimation of reference intervals for thyroid parameters using advia centaur XP analyzer.Journal of medical biochemistry · 2022Article
- Severe radiation thyroiditis after radioactive iodine for treatment of Graves' disease.Singapore medical journal · 2021Article
- Diagnostic Utility of Mean Peak Systolic Velocity of Superior Thyroid Artery in Differentiating Graves' Disease from Thyroiditis.The Indian journal of radiology & imaging · 2021Article
- Establishing a diagnostic scale of subacute thyroiditis without radioisotope scanning.BMC endocrine disorders · 2020Article
- Serum Ratio of Free Triiodothyronine to Thyroid-Stimulating Hormone: A Novel Index for Distinguishing Graves' Disease From Autoimmune Thyroiditis.Frontiers in endocrinology · 2020Article
- Eosinophil/Monocyte Ratio Combined With Serum Thyroid Hormone for Distinguishing Graves' Disease and Subacute Thyroiditis.Frontiers in endocrinology · 2020Article
- Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study.JAMA cardiology · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe results of previous studies on the usefulness of free triiodothyronine (FT3) to free thyroxine (FT4) are controversial. We investigated the usefulness of FT3, FT4, and FT3/FT4 ratio in differentiating Graves' disease (GD) from destructive thyroiditis.
methodsA total of 126 patients with untreated GD, 36 with painless thyroiditis, 18 with painful subacute thyroiditis, and 63 healthy controls, were recruited. The levels of FT3 and FT4 and the FT3/FT4 ratios for the different etiologies of thyrotoxicosis were evaluated separately by receiver operating characteristic (ROC) curve analysis. The expression levels of type 1 and type 2 deiodinase (
resultsThe optimal cut-off values were 7.215 pmol/L for FT3, 21.71 pmol/L for FT4, and 0.4056 for the FT3/FT4 ratio. The specificity and positive predictive value of the FT3/FT4 ratio were highest for values > 0.4056.
conclusionsWe demonstrated that the FT3/FT4 ratio was useful in differentiating GD from destructive thyroiditis. In addition, a relatively high expression of type 1 deiodinase in the thyroid might be responsible for the high FT3/FT4 ratio in patients with GD.
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