Evidence map›Paper›PMID 29970880›Full record

ArticleCell death & disease2018

Consequences of blunting the mevalonate pathway in cancer identified by a pluri-omics approach.

Sophie Goulitquer, Mikaël Croyal, Julie Lalande, Anne-Lise Royer, Yann Guitton, Danielle Arzur, Stéphanie Durand, Catherine Le Jossic-Corcos, Alain Bouchereau, Philippe Potin and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Role ofQuantitative biology (Beijing, China) · 2024
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  8. Curbing Lipids: Impacts ON Cancer and Viral Infection.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Sophie GoulitquerGénétique, Génomique Fonctionnelle et Biotechnologies, INSERM, Université de Brest, EFS, Brest, France.
Mikaël CroyalINRA UMR 1280, Centre de Recherche en Nutrition Humaine de l'Ouest (CRNHO), CHU Hôtel-Dieu, Université de Nantes, Nantes, France.
Julie LalandeCEISAM UMR 6230, EBSI Team, Université de Nantes, CNRS, Nantes, France.
Anne-Lise RoyerLaboratoire d'Etude des Résidus et Contaminants dans les aliments (LABERCA), Ecole Nationale Vétérinaire, Agroalimentaire et de l'Alimentation Nantes Atlantique (Oniris), Nantes, France.
Yann GuittonLaboratoire d'Etude des Résidus et Contaminants dans les aliments (LABERCA), Ecole Nationale Vétérinaire, Agroalimentaire et de l'Alimentation Nantes Atlantique (Oniris), Nantes, France.ORCID 0000-0002-4479-0636
Danielle ArzurGénétique, Génomique Fonctionnelle et Biotechnologies, INSERM, Université de Brest, EFS, Brest, France.
Stéphanie DurandGénétique, Génomique Fonctionnelle et Biotechnologies, INSERM, Université de Brest, EFS, Brest, France.
Catherine Le Jossic-CorcosGénétique, Génomique Fonctionnelle et Biotechnologies, INSERM, Université de Brest, EFS, Brest, France.
Alain BouchereauInstitut de Génétique, Environnement et Protection des Plantes, UMR 1349 INRA-Agrocampus Ouest-Université de Rennes 1, Rennes-Le Rheu, France.
Philippe PotinTeam Biochemistry of Algal Defenses, UMR 7139 CNRS-UPMC & LIA-DIAMS, Station Biologique, Roscoff, France.
Serge AkokaCEISAM UMR 6230, EBSI Team, Université de Nantes, CNRS, Nantes, France.
Jean-Philippe AntignacLaboratoire d'Etude des Résidus et Contaminants dans les aliments (LABERCA), Ecole Nationale Vétérinaire, Agroalimentaire et de l'Alimentation Nantes Atlantique (Oniris), Nantes, France.
Michel KrempfINRA UMR 1280, Centre de Recherche en Nutrition Humaine de l'Ouest (CRNHO), CHU Hôtel-Dieu, Université de Nantes, Nantes, France.
Véronique Ferchaud-RoucherINRA UMR 1280, Centre de Recherche en Nutrition Humaine de l'Ouest (CRNHO), CHU Hôtel-Dieu, Université de Nantes, Nantes, France.
Patrick GiraudeauCEISAM UMR 6230, EBSI Team, Université de Nantes, CNRS, Nantes, France.
Laurent CorcosGénétique, Génomique Fonctionnelle et Biotechnologies, INSERM, Université de Brest, EFS, Brest, France. laurent.corcos@inserm.fr.
Inserm · FRCentre National de la Recherche Scientifique · FRLaboratoire D'étude des Résidus et Contaminants Dans les Aliments · FRCentre de Recherche en Nutrition Humaine Rhône-Alpes · FRInstitut Agro Rennes-Angers · FRUniversité Nantes Angers Le Mans · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously shown that the combination of statins and taxanes was a powerful trigger of HGT-1 human gastric cancer cells' apoptosis

Indexed as

AnimalsChromatography, LiquidGas Chromatography-Mass SpectrometryHumansMagnetic Resonance SpectroscopyMetabolic Networks and PathwaysMetabolomicsMevalonic AcidTandem Mass SpectrometryMevalonic Acid

Identifiers

PMID29970880
PMCPMC6030166
OpenAlexW2809708823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.