Evidence map›Paper›PMID 29970504›Full record

ArticleAnticancer research2018

Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae.

Andrew T Meram, Jie Chen, Stavan Patel, Dongsoo D Kim, Brett Shirley, Paul Covello, Domenico Coppola, Eric X Wei, Ghali Ghali, Christopher G Kevil and 1 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Anticancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Hydrogen Sulfide Metabolism in the Skin: From Physiology to Malignancy.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer.Redox report : communications in free radical research · 2024
    Review
  9. Pan-inhibition of the three HCancer cell international · 2024
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Hydrogen Sulfide Biology and Its Role in Cancer.Molecules (Basel, Switzerland) · 2022
    Review
  16. Article
  17. Role of Hydrogen Sulfide in Oral Disease.Oxidative medicine and cellular longevity · 2022
    Review
  18. Methods in sulfide and persulfide research.Nitric oxide : biology and chemistry · 2021
    Article
  19. Article
  20. Molecular Functions of Hydrogen Sulfide in Cancer.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Andrew T MeramHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Jie ChenDepartment of Pathology and Translational Pathobiology Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Stavan PatelHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Dongsoo D KimHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Brett ShirleyHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Paul CovelloHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Domenico CoppolaDepartment of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A.
Eric X WeiDepartment of Pathology and Translational Pathobiology Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Ghali GhaliHead & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Christopher G KevilDepartment of Pathology and Translational Pathobiology Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Rodney E ShackelfordDepartment of Pathology and Translational Pathobiology Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A. rshack@lsuhsc.edu.
Moffitt Cancer Center · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Hydrogen sulfide and vascular remodelingR01HL113303 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI KEVIL, CHRISTOPHER G · 2012 to 2016
$1.8M
NCI NIH HHS P30 CA076292NHLBI NIH HHS R01 HL113303
6 · The paper itself

Abstract

BACKGROUND/

aimHydrogen sulfide (H PATIENTS AND

methodsPunch biopsies of OSCC and benign mucosae from 15 patients were analyzed by HPLC, western blotting, and tissue microarray analyses.

resultsH

conclusionH

Indexed as

AgedAged, 80 and overBlotting, WesternCarcinoma, Squamous CellChromatography, High Pressure LiquidHumansHydrogen SulfideMiddle AgedMouth MucosaMouth NeoplasmsTissue Array AnalysisHydrogen Sulfide3-mercaptopyruvatecystathionine-β-synthasecystathionine γ-lyaseH2SHydrogen sulfidemitoNEET

Identifiers

PMID29970504
PMCPMC7771275
OpenAlexW2811195282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.