ArticleBiology open2018
Epigenetic modifications by polyphenolic compounds alter gene expression in the hippocampus.
Article in Biology open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Protocol for a randomized, controlled trial of a bioactive dietary polyphenol preparation to promote resilience in healthy individuals.Contemporary clinical trials · 2026Article
- Epigenetic and Neurogenomic Mechanisms Linking Physical Activity to Brain Plasticity and Cognitive Function.Genes · 2026Review
- Anticancer Activity ofBiomolecules · 2025Article
- Molecular mechanisms underlying the neuroprotective effects of polyphenols: implications for cognitive function.EXCLI journal · 2025Review
- Dietary polyphenols drive dose-dependent behavioral and molecular alterations to repeated morphine.Scientific reports · 2023Article
- Natural antioxidants that act against Alzheimer's disease through modulation of the NRF2 pathway: a focus on their molecular mechanisms of action.Frontiers in endocrinology · 2023Review
- Small phenolic and indolic gut-dependent molecules in the primate central nervous system: levels vs. bioactivity.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Targeting DNA Methylation in the Adult Brain through Diet.Nutrients · 2021Review
- Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17/Treg) imbalance promoting resilience to stress-induced anxiety- and depressive-like behaviors.Brain, behavior, and immunity · 2021Article
- Metabolites Secreted by a Plant-Growth-PromotingFrontiers in microbiology · 2020Article
- Dietary Antioxidant Supplementation Promotes Growth in Senegalese Sole Postlarvae.Frontiers in physiology · 2020Article
- Grape-derived polyphenols produce antidepressant effects via VGF- and BDNF-dependent mechanisms.Annals of the New York Academy of Sciences · 2019Article
- Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring.International journal of molecular sciences · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In this study, we developed an experimental protocol leveraging enhanced reduced representation bisulphite sequencing to investigate methylation and gene expression patterns in the hippocampus in response to polyphenolic compounds. We report that the administration of a standardized bioavailable polyphenolic preparation (BDPP) differentially influences methylated cytosine patterns in introns, UTR and exons in hippocampal genes. We subsequently established that dietary BDPP-mediated changes in methylation influenced the transcriptional pattern of select genes that are involved in synaptic plasticity. In addition, we showed dietary BDPP mediated changes in the transcriptional pattern of genes associated with epigenetic modifications, including members of the DNA methyl transferase family (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.