Evidence map›Paper›PMID 29970468›Full record

ArticlemBio2018

Type 2 NADH Dehydrogenase Is the Only Point of Entry for Electrons into the Streptococcus agalactiae Respiratory Chain and Is a Potential Drug Target.

Andrea M Lencina, Thierry Franza, Matthew J Sullivan, Glen C Ulett, Deepak S Ipe, Philippe Gaudu, Robert B Gennis, Lici A Schurig-Briccio

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. NQR as a target for new antibiotics.Frontiers in microbiology · 2025
    Review
  7. Inhibitors of Type II NADH Dehydrogenase Enzyme: A Review.Current protein & peptide science · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. The respiratory chain ofFrontiers in microbiology · 2024
    Article
  12. Infection and immunity · 2023
    Article
  13. bioRxiv : the preprint server for biology · 2023
    Article
  14. eLife · 2022
    Article
  15. Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Frontiers in genetics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Andrea M LencinaDepartment of Biochemistry, University of Illinois, Urbana, Illinois, USA.
Thierry FranzaMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
Matthew J SullivanSchool of Medical Sciences and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
Glen C UlettSchool of Medical Sciences and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.ORCID 0000-0002-9638-8091
Deepak S IpeSchool of Medical Sciences and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
Philippe GauduMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.ORCID 0000-0002-9061-7316
Robert B GennisDepartment of Biochemistry, University of Illinois, Urbana, Illinois, USA.ORCID 0000-0002-3805-6945
Lici A Schurig-BriccioDepartment of Biochemistry, University of Illinois, Urbana, Illinois, USA lschurig@illinois.edu.ORCID 0000-0002-5514-2298
Griffith University · AUUniversity of Illinois Urbana-Champaign · USAgroParisTech · FR

Funding

PROTEIN/LIPID INTERACTIONSR01HL016101 · NHLBI · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI GENNIS, ROBERT B · 1985 to 2015
$6.8M
PROTEIN/LIPID INTERACTIONSR37HL016101 · NHLBI · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI GENNIS, ROBERT B. · 1993 to 2002
$1.5M
Using extreme thermophiles for the homologous expression of membrane proteinsR01GM095600 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GENNIS, ROBERT B · 2010 to 2013
$1.1M
NHLBI NIH HHS R01 HL016101NHLBI NIH HHS R37 HL016101NIGMS NIH HHS R01 GM095600
6 · The paper itself

Abstract

The opportunistic pathogen

Indexed as

Electron TransportAnimalsDisease Models, AnimalMiceNADH DehydrogenaseOxidation-ReductionOxygenStreptococcal InfectionsStreptococcus agalactiaeVirulence FactorsWaterNADH DehydrogenaseNADH dehydrogenase IIOxygenVirulence FactorsWaterbacterial pathogenesisdrug discoveryelectron transport chainNADH dehydrogenaseStreptococcus agalactiae

Identifiers

PMID29970468
PMCPMC6030563
OpenAlexW2811399003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.