ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2018
Impact of a single eGFR and eGFR-estimating equation on chronic kidney disease reclassification: a cohort study in primary care.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Association of triglyceride-glucose index and high-sensitivity C-reactive protein with contrast-induced nephropathy after percutaneous coronary intervention in patients with acute coronary syndrome: a retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Global burden and risk factors of chronic kidney disease in adolescents and young adults: a study from 1990 to 2019.Kidney research and clinical practice · 2025Article
- Incident chronic kidney disease among Canadian immigrants: a population-based cohort study.BMJ public health · 2024Article
- Global, regional, and national burden of kidney dysfunction from 1990 to 2019: a systematic analysis from the global burden of disease study 2019.BMC public health · 2023Article
- Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study.BMJ (Clinical research ed.) · 2023Article
- A 5-Year Follow-Up Study to Explore Factors Associated with Rapid Kidney Function Decline Among Bus Drivers.International journal of general medicine · 2023Article
- Sex-specific associations between potassium intake, blood pressure, and cardiovascular outcomes: the EPIC-Norfolk study.European heart journal · 2022Article
- Article
- National Trends in the Prevalence of Chronic Kidney Disease Among Racial/Ethnic and Socioeconomic Status Groups, 1988-2016.JAMA network open · 2020Article
- Prevalence of chronic kidney disease in the community using data from OxRen: a UK population-based cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Observational
- Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.Lancet (London, England) · 2020 · on this mapArticle
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundChronic kidney disease (CKD) is diagnosed using the estimated glomerular filtration rate (eGFR) and the urinary albumin:creatinine ratio (ACR). The eGFR is calculated from serum creatinine levels using the Modification of Diet in Renal Disease (MDRD) or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations.
aimTo compare the performance of one versus two eGFR/ACR measurements, and the impact of equation choice, on CKD diagnosis and classification. DESIGN AND
settingCohort study in primary care in the Thames Valley region of the UK.
methodData were from 485 participants aged >60 years in the Oxford Renal Cohort Study with at least two eGFR tests. The proportion of study participants diagnosed and classified into different CKD stages using one and two positive tests were compared. Prevalence of CKD diagnosis and classification by CKD stage were compared when eGFR was calculated using MDRD and CKD-EPI equations.
resultsParticipants included in the analysis had a mean age of 72.1 (±6.8) years and 57.0% were female. Use of a single screening test overestimated the proportion of people with CKD by around 25% no matter which equation was used, compared with the use of two tests. The mean eGFR was 1.4 ml/min/1.73 m
conclusionCurrent guidance to use two eGFR measures to diagnose CKD remains appropriate in an older primary care population to avoid overdiagnosis. A change from MDRD to CKD-EPI equation could result in one in 12 patients with a CKD diagnosis with MDRD no longer having a diagnosis of CKD.
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