Observational studyAtherosclerosis2018
Ultrasound carotid plaque features, cardiovascular disease risk factors and events: The Multi-Ethnic Study of Atherosclerosis.
Observational study in Atherosclerosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- The influence of burnout on cardiovascular disease: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Macrovascular damage in polymyalgia rheumatica: integrated vascular phenotyping in the POLYMYACARD cohort.Arthritis research & therapy · 2026Article
- Endothelial Dysfunction and Obesity: New Diagnostic and Therapeutic Strategies.International journal of molecular sciences · 2026Review
- Clinical-Metabolic Risk Phenotypes and Carotid Plaque Burden Among Community-Dwelling Individuals at High Cardiovascular Risk: An Exploratory Cross-Sectional Study.Journal of cardiovascular development and disease · 2026Article
- Cerebrovascular Risk Factors for Body Mass Index, Diabetes, and Atherosclerosis in a Wisconsin Native American Population: A Cross-Sectional Observation Study.Journal of the American Heart Association · 2026Observational
- Novel Cerebrovascular Disease Blood Biomarkers Identified by Targeted Proteomics in a High-Risk Native American Population.World neurosurgery · 2026Article
- Dual-modal ultrasound radiomics model enhances identification of symptomatic carotid plaque: a multicenter retrospective study.The international journal of cardiovascular imaging · 2026Article
- Biomarker value of plasma endothelial microvesicle-derived circRNA 0006222 in vascular ageing and carotid atherosclerosis.Frontiers in neuroscience · 2026Article
- Carotid plaque number and length as predictors of coronary heart disease in patients with early-stage chronic kidney disease.Frontiers in cardiovascular medicine · 2026Article
- Association between inflammatory cytokines and carotid plaque in young and middle-aged adults.Biochemistry and biophysics reports · 2025Article
- Future of Families: Cardiovascular Health Among Young Adults Cohort Study: Rationale, Key Questions, Study Design, and Participant Characteristics.Journal of the American Heart Association · 2025Article
- Everyday discrimination and subclinical indicators of stroke in midlife women.Journal of behavioral medicine · 2025Article
- Associations of the triglyceride-glucose index and remnant cholesterol levels with the prevalence of Carotid Plaque in patients with type 2 diabetes: a retrospective study.Lipids in health and disease · 2025Article
- Study on the prediction of short-term clinical changes after cerebral infarction using carotid plaque ultrasound strain elastography.Frontiers in neurology · 2025Article
- Carotid calcifications in panoramic radiographs can predict vascular risk.Dento maxillo facial radiology · 2025Article
- Discrimination, Smoking, and Cardiovascular Disease Risk: A Moderated Mediation Analysis With MESA.Journal of the American Heart Association · 2024Article
- Peripheral Artery Disease Ultrasound Assessment in Predicting the Severity of Coronary Artery Disease.Life (Basel, Switzerland) · 2024Review
- Racial and ethnic influences on carotid atherosclerosis: Epidemiology and risk factors.SAGE open medicine · 2024Review
- The association between metabolic dysfunction-associated steatotic liver disease, cardiovascular and cerebrovascular diseases and the thickness of carotid plaque.BMC cardiovascular disorders · 2023Article
- Imaging and Hemodynamic Characteristics of Vulnerable Carotid Plaques and Artificial Intelligence Applications in Plaque Classification and Segmentation.Brain sciences · 2023Review
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsIt is not known if ultrasound carotid plaque features are associated with cardiovascular disease (CVD) risk factors or if they predict future CVD events.
methodsWe measured total carotid plaque area (TPA) and grayscale plaque features (grayscale median, black areas, and discrete white areas) by B-mode carotid ultrasound among 2205 participants who participated in the first (baseline) visit of the Multi-Ethnic Study of Atherosclerosis. Multivariable linear regression was used to examine relationships between ultrasound plaque features and CVD risk factors at baseline. Cox proportional hazards models were used to assess if TPA, grayscale features, and carotid plaque score (number of arterial segments with a plaque) could predict incident coronary heart disease and cerebrovascular disease events over a mean follow-up of 13.3 years.
resultsParticipants were mean (standard deviation [SD]) 65.4 (9.6) years, 49% male, 39% White, 11% Chinese, 28% Black, and 22% Hispanic. Mean TPA 27.7 (24.7) mm
conclusionsIn middle-aged adults free of known cardiovascular disease, TPA but not grayscale plaque features was associated with CVD risk factors and predicted incident CHD events. For CHD, prediction indices for TPA were similar to carotid plaque score but less than for CAC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.