Evidence map›Paper›PMID 29970179›Full record

ArticleVeterinary research2018

Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection.

Isabel L Pacheco, Nieves Abril, Rafael Zafra, Verónica Molina-Hernández, Noelia Morales-Prieto, María J Bautista, María T Ruiz-Campillo, Raúl Pérez-Caballero, Alvaro Martínez-Moreno, José Pérez

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Evaluation ofVaccines · 2025
    Article
  2. A Modified Variant ofVaccines · 2025
    Article
  3. Harnessing mRNA technology againstFrontiers in immunology · 2025
    Article
  4. Liver Histopathological and Immunohistochemical Evaluation fromAnimals : an open access journal from MDPI · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Proteomic analysis ofFrontiers in microbiology · 2022
    Article
  9. Article
  10. A Partially Protective Vaccine forAnimals : an open access journal from MDPI · 2021
    Article
  11. Article
  12. Pathobiology and diagnosis of clostridial hepatitis in animals.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020
    Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Isabel L PachecoDepartment of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, University of Córdoba, Sanidad Animal Building, Rabanales Campus, Córdoba, Spain.
Nieves AbrilDepartment of Biochemistry and Molecular Biology, Faculty of Sciences, University of Córdoba, Severo Ochoa Building, Rabanales Campus, Córdoba, Spain.
Rafael ZafraDepartment of Animal Health (Parasitology), Faculty of Veterinary Medicine, University of Córdoba, Sanidad Animal Building, Rabanales Campus, Córdoba, Spain.
Verónica Molina-HernándezDepartment of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, University of Córdoba, Sanidad Animal Building, Rabanales Campus, Córdoba, Spain.
Noelia Morales-PrietoDepartment of Biochemistry and Molecular Biology, Faculty of Sciences, University of Córdoba, Severo Ochoa Building, Rabanales Campus, Córdoba, Spain.
María J BautistaDepartment of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, University of Córdoba, Sanidad Animal Building, Rabanales Campus, Córdoba, Spain.
María T Ruiz-CampilloDepartment of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, University of Córdoba, Sanidad Animal Building, Rabanales Campus, Córdoba, Spain.
Raúl Pérez-CaballeroDepartment of Animal Health (Parasitology), Faculty of Veterinary Medicine, University of Córdoba, Sanidad Animal Building, Rabanales Campus, Córdoba, Spain.
Alvaro Martínez-MorenoDepartment of Animal Health (Parasitology), Faculty of Veterinary Medicine, University of Córdoba, Sanidad Animal Building, Rabanales Campus, Córdoba, Spain.
José PérezDepartment of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, University of Córdoba, Sanidad Animal Building, Rabanales Campus, Córdoba, Spain. an1pearj@uco.es.
University of Córdoba · ES

Funding

EU grant PARAGONE H2020-635408-PARAGONENational grant AGL2015-67023-C2-1-R
6 · The paper itself

Abstract

The expression of T regulatory cells (Foxp3), regulatory (interleukin [IL]-10 and transforming growth factor beta [TGF-β]) and proinflammatory (tumor necrosis factor alpha [TNF-α] and interleukin [IL]-1β) cytokines was quantified using real time polymerase chain reaction (qRT-PCR) in the liver of sheep during early stages of infection with Fasciola hepatica (1, 3, 9, and 18 days post-infection [dpi]). Portal fibrosis was also evaluated by Masson's trichrome stain as well as the number of Foxp3

Indexed as

Gene ExpressionAnimalsCytokinesFasciola hepaticaFascioliasisForkhead Transcription FactorsLiverSheepSheep DiseasesCytokinesForkhead Transcription Factors

Identifiers

PMID29970179
PMCPMC6029414
OpenAlexW2810021549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.