Evidence map›Paper›PMID 29970177›Full record

ArticleBiology of sex differences2018

Human osteoblasts exhibit sexual dimorphism in their response to estrogen on microstructured titanium surfaces.

Michael B Berger, David J Cohen, Rene Olivares-Navarrete, Joseph K Williams, David L Cochran, Barbara D Boyan, Zvi Schwartz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sex differences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Sex Difference in OA: Should We Blame Estrogen?European journal of rheumatology · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Surface properties and bioactivity of TiORoyal Society open science · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Michael B BergerDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 West Main Street, Richmond, VA, 23284-3068, USA.
David J CohenDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 West Main Street, Richmond, VA, 23284-3068, USA.
Rene Olivares-NavarreteDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 West Main Street, Richmond, VA, 23284-3068, USA.
Joseph K WilliamsChildren's Healthcare of Atlanta, Atlanta, GA, 30332, USA.
David L CochranDepartment of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Barbara D BoyanDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 West Main Street, Richmond, VA, 23284-3068, USA. bboyan@vcu.edu.ORCID 0000-0002-9642-0311
Zvi SchwartzDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 West Main Street, Richmond, VA, 23284-3068, USA.
Virginia Commonwealth University · USThe University of Texas Health Science Center at San Antonio · USChildren's Healthcare of Atlanta · US

Funding

Mechanisms of Cell/Surface InteractionR01AR052102 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI BOYAN, BARBARA D. · 2006 to 2015
$3.3M
Mechanisms Mediating Osseointegration of 3D Printed Titanium ConstructsR01AR072500 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI BOYAN, BARBARA D. · 2019 to 2023
$2.9M
NIAMS NIH HHS R01 AR052102NIAMS NIH HHS R01 AR072500
6 · The paper itself

Abstract

backgroundOsseointegration is dependent on the implant surface, surrounding bone quality, and the systemic host environment, which can differ in male and female patients. Titanium (Ti) implants with microstructured surfaces exhibit greater pullout strength when compared to smooth-surfaced implants and exhibit enhanced osteogenic cellular responses in vitro. Previous studies showed that 1α,25-dihydroxyvitamin D3 [1α,25(OH)

methodsOsteoblasts from three male and three female human donors were cultured on Ti discs with varying surface profiles: a smooth pretreatment (PT), a coarse grit-blasted/acid-etched (SLA), and an SLA surface having undergone modification in a nitrogen environment and stored in saline to maintain hydrophilicity (modSLA). Cells cultured on these surfaces were treated with E

resultsMale and female human osteoblasts responded similarly to microstructure although there were donor-specific differences; cell number decreased, and osteocalcin (OCN), osteoprotegerin (OPG), and latent and active transforming growth factor 1 increased on SLA and modSLA compared to TCPS. Female osteoblasts had higher alkaline phosphatase activity and OCN production than male counterparts but produced less OPG. Both sexes responded similarly to 1α,25(OH)

conclusionsMale and female human osteoblasts respond similarly to microstructure and 1α,25(OH)

Indexed as

Sex CharacteristicsTitaniumBiocompatible MaterialsCells, CulturedEstradiolEstrogensHumansOsteoblastsOsteocalcinOsteoprotegerinSurface PropertiesVitamin DBiocompatible Materialsdihydroxy-vitamin D3EstradiolEstrogensOsteocalcinOsteoprotegerinTitaniumVitamin D1,25-Dihydroxy vitamin D3EstradiolHormonesHuman osteoblastsSex-specific responsesTitanium surface roughness

Identifiers

PMID29970177
PMCPMC6029108
OpenAlexW2811324788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.