Evidence map›Paper›PMID 29970142›Full record

ArticleTrials2018

Effects of a 6-week, whole-body vibration strength-training on depression symptoms, endocrinological and neurobiological parameters in adolescent inpatients experiencing a major depressive episode (the "Balancing Vibrations Study"): study protocol for a randomized placebo-controlled trial.

Max Oberste, Nicola Großheinrich, Heidrun-Lioba Wunram, Johannes Levin Graf, Alischa Ziemendorff, Axel Meinhardt, Oliver Fricke, Esther Mahabir, Stephan Bender

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Whole Body Vibration: A Valid Alternative Strategy to Exercise?Journal of functional morphology and kinesiology · 2022
    Review
  7. Article
  8. Article
  9. Review
  10. Depression in Adolescence and Brain-Derived Neurotrophic Factor.Frontiers in molecular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Max ObersteDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Robert-Koch-Straße 10, 50931, Cologne, Germany. max.oberste-frielinghaus@uk-koeln.de.ORCID http://orcid.org/0000-0002-1224-5385
Nicola GroßheinrichDepartment of Social Sciences, Catholic University of Applied Science of North Rhine - Westphalia, Wörthstraße 10, 50688, Cologne, Germany.
Heidrun-Lioba WunramDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Robert-Koch-Straße 10, 50931, Cologne, Germany.
Johannes Levin GrafDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Robert-Koch-Straße 10, 50931, Cologne, Germany.
Alischa ZiemendorffDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Robert-Koch-Straße 10, 50931, Cologne, Germany.
Axel MeinhardtDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Robert-Koch-Straße 10, 50931, Cologne, Germany.
Oliver FrickeChair of Child and Adolescent Psychiatry, Witten/Herdecke University and Department of Child and Adolescent Psychiatry, Psychotherapy and Child Neurology, Gemeinschaftskrankenhaus Herdecke, Gerhard-Kienle-Weg 4, 58313, Herdecke, Germany.
Esther MahabirComparative Medicine, Center for Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 21, Cologne, Germany.
Stephan BenderDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Robert-Koch-Straße 10, 50931, Cologne, Germany.
University of Cologne · DECatholic University of Applied Social Sciences · DEWitten/Herdecke University · DE

Funding

The Marga and Walter Boll-Stiftung project number: 210-07.2-11
6 · The paper itself

Abstract

backgroundModerate to vigorous endurance and strength-training exercise was suggested as a treatment option for major depression. However, there is little evidence to support this suggestion in adolescent patients. The present study investigates the effects of a whole-body vibration strength-training intervention on symptoms in medication-naïve adolescent inpatients experiencing a major depressive episode. Potential underlying endocrinological and neurobiological mechanisms are explored. METHODS/

designA double-blinded randomized controlled trial is conducted at the University Hospital of Cologne in Germany, comparing a 6-week, whole-body vibration strength-training with a 6-week placebo-intervention, as add-on therapy to inpatient treatment as usual. Forty-one subjects (13-18 years of age) will be included in each of the two groups. The study is powered to detect (α = .05, β = .2) a medium effect size difference between the two groups (d = .5) in terms of patients' change in the Children's Depression Rating Scale raw-score, from baseline until the end of the intervention. As secondary endpoints, the effects of exercise treatment on patients' cortisol awakening response as well as on brain-derived neurotrophic factor, insulin-like growth factor 1 and inflammatory markers (tumor necrosis factor-alpha, interleukin-6 and C-reactive protein) serum levels will be assessed. DISCUSSION: This study will provide evidence on the effectiveness of whole-body vibration strength-training as an add-on therapy in adolescent inpatients experiencing a major depressive episode. After completion of data collection, the present study will be the largest randomized controlled trial so far to investigate the effectiveness of an exercise intervention in inpatient adolescents suffering from a major depressive episode. Moreover, the present study may help to determine the underlying mechanisms of potential anti-depressant effects of exercise in depressed adolescent inpatients.

trial registrationDRKS.de, German Clinical Trials Register (DRKS), Identifier: DRKS00011772 . Registered on 20 March 2017.

Indexed as

Adolescent BehaviorAdolescentAge FactorsBiomarkersBrain-Derived Neurotrophic FactorDouble-Blind MethodGermanyHumansHydrocortisoneInflammation MediatorsInpatientsInsulin-Like Growth Factor IMajor Depressive DisorderMaleRandomized Controlled Trials as TopicResistance TrainingBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorHydrocortisoneIGF1 protein, humanInflammation MediatorsInsulin-Like Growth Factor IAdolescenceCortisolExerciseInflammatory markersMajor depressionNeurotrophinsWhole-body vibration

Identifiers

PMID29970142
PMCPMC6029053
OpenAlexW2810179949

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.